He was a regular, playing Mark Judd in the 2nd series of Chandler & Co during 1995 and playing Dr David Shearer in Peak Practice between 1997 and 1999. He also played Mr. George Wickham in the BBC's 1995 adaption of Jane Austen's Pride and Prejudice, and he had appeared in the ITV one-off drama Back Home and in the BBC rural drama series Down to Earth.

He had previously appeared in The Casebook of Sherlock Holmes (as Bennett in The Creeping Man), Maigret, Miss Marple, Campion, The Strauss Dynasty and Prime Suspect. Adrian Lukis played Simon Avery in Silent Witness Series 15 Episode 2, Death Has No Dominion. For radio, he appeared as George Vavasour in BBC Radio 4's 2004 adaptation of Anthony Trollope's The Pallisers.

In 2015, Lukis appeared as Francis Davison in the BBC TV series Death in Paradise episode 4.3, and appeared as Laurence Olivier in the European premiere of the Austin Pendleton play Orson's Shadow, at the Southwark Playhouse in London. In 2016, he appeared as Home Secretary Alex Wallis in "Hated in the Nation", an episode of the anthology series Black Mirror.