Adrienne Wilkinson is best known for her role of Livia/Eve, the sometimes-warrior-sometimes-saint daughter of Xena on Xena: Warrior Princess. She started on television in an episode of Sweet Valley High in 1996, and moved on to Saved By The Bell: The New Class, Chicken Soup for the Soul and in 2001 she had several guest appearances on Undressed. In 2002 she starred as Nikki on the US version of As If. In 2003 she had a guest spot on Angel as a cheeky flapper from the 1920s, and as Linda Browning in an episode of Days of Our Lives. In 2005 she had guest appearances on Charmed as Phoebe Halliwell's first disguise of the season, Eyes and was a temporary love interest of Dr. Ray Barnett on ER, and Paisley Parker on Goodnight Burbank. She is a series regular on Venice: The Series playing Adrienne, who appears in seasons 2–4.

She moved to Los Angeles, California to pursue acting after graduating from high school. She was two years old when she started taking dance lessons and performed on stage as a Dancer throughout her youth until she moved to Los Angeles to become an Actress. She has two younger sisters and a younger brother. Her younger sister, Tracey Bradley, is a Director and Producer for Pulse Studios. Her youngest sister, Aimee Wilkinson, is a musician. The three sisters worked on the film Expectation together in 2005.

In 2008, she starred in the short film Reflections, directed by Barry Caldwell. She received two acting awards for her performance, and an additional two nominations.

In 2011, Wilkinson created From The Mouths of Babes, an online interview series that collects impromptu interviews that address Love, Life, and Self. The project launched on YouTube on May 15, 2012 under the user ID mouthsofbabesnet. As of September 2014, the channel has surpassed 100,000 views.

From the Mouths of Babes began to release compilation episodes in September 2013, starting with "Xena on Love." Season one wrapped in October 2014, and season 2 is currently airing on YouTube.