Sulkin, along with Family Guy Writers Julius Sharpe, Danny Smith, John Viener, Patrick Meighan and Seth MacFarlane were special material Writers for the 85th Academy Awards, in which the latter was the host.

Sulkin joined Family Guy in 2005, and has since produced, written and provided voices for multiple episodes, including the hour-long Star Wars homage, "Blue Harvest", as well as "Chick Cancer", "Stew-Roids", "Stu and Stewie's Excellent Adventure", "Screams of Silence: The Story of Brenda Q", "Family Guy Viewer Mail #2" (with Tom Devanney and Deepak Sethi), "Into Fat Air", Grimm Job and 3 Acts of God.

In August, 2010, Sulkin and his writing partner Wellesley Wild signed a three-year pact with 20th Century Fox TV. The two will continue working on Family Guy and also develop their own show. It is likely to be live action comedy rather than animation, although Wild said "We've been throwing around both ideas." In 2013, Sulkin and Wild produced a sitcom titled Dads, with MacFarlane as executive Producer. The series was cancelled after one season. In 2012, Sulkin co-wrote the well-received comedy Ted, along with MacFarlane and Wild.

In March 2011, Sulkin caused a controversy by posting the following joke on Twitter: "If you wanna feel better about this earthquake in Japan, google 'Pearl Harbor death toll.'" Sulkin made the comment one day after the 2011 Tōhoku earthquake, which killed over 10,000 people in Japan. The following day, Sulkin deleted the joke and apologized, saying the post was insensitive and that he had not realized the extent and severity of the disaster.

Sulkin co-wrote the script of the 2014 film A Million Ways to Die in the West, along with MacFarlane and Wild.