Andrea Berloff was born to a Jewish family in Framingham, Massachusetts in 1974. She attended Framingham South High School until she graduated in 1991. Upon graduating high school, Berloff attended Cornell University to study drama which she then graduated from in 1995.

Lastly, she was nominated for Best Original Screenplay at the 88th Academy Awards alongside Herman, Savidge and Wenkus.

Berloff's brief acting career began shortly after she graduated from college. In 1997, she played the role of the Nameless sister in the Tisch School of the Arts produced film Growth, directed by Joel Hopkins.

In 2001, Berloff was cast in a minor role as a popular high school girl for the short film Eyeball Eddie, directed by Elizabeth Allen Rosenbaum. The film starred Martin Starr and depicted the story of a boy named Eddie with a prosthetic glass eye, who discovers the benefits of using his glass eye as a diversion tactic in his wrestling competitions.

In 2002, Berloff along with Drew Filus, co-wrote the short film Domestic, in which Filus also acted as Director. The film depicted the story of a man trying to find a model who recently left him.

Berloff married fellow Cornell University student, Drew Filus, in 2004. Together they have two children, Dashiell and Sasha. Berloff now resides in Los Angeles with her husband and two children.

In 2005, Berloff acted as the executive Producer and played the role of Dr. Schwartz in the independent film Raw Footage, directed by Drew Filus. The film acted as Berloff's producing debut in the film industry. Raw footage depicts a family reunion at the renewal of a family member's marriage vows in California. Raw Footage went on to win the Audience Award for Best Feature at the Washington DC Independent Film Festival.

In 2006, Empire reported that she had been hired to write the screenplay for Ridley Scott's upcoming biopic on the Italian fashion designer Aldo Gucci. The film is still in development and has faced many concerns, specifically from some of the Gucci family members, regarding the portrayal of their family. The film has yet to begin production in light of all these concerns.

In 2013, Deadline Hollywood reported that Berloff was tasked with writing the screenplay for Universal Studios’ Legend of Conan. The film will serve as a sequel to the 1982 film Conan The Barbarian but will ignore the 1984 sequel Conan The Destroyer and the 2011 reboot starring Jason Momoa. The film will see the return of Arnold Schwarzenegger, taking on the role of Conan once again after more than three decades from the initial film’s release. The film is still in development and has no set date for production or release just yet.

In 2015, Empire reported that Berloff, along with story Writer Nicolas Saada, was hired to write the screenplay for the film Sleepless, directed by Baran bo Odar. The film serves as a remake to the 2011 French thriller film Nuit Blanche. Sleepless Night is set to release in 2016 and will starr Jamie Foxx as a cop whose family comes in danger after he betrays his connections in the Criminal underworld.

In 2016, Berloff was nominated for several awards for her work on Straight Outta Compton: