Jeremiah has stated that her focus was always on music, that she chose to be a professional singer and that acting happened by chance. In 2005, she ventured into playback singing in feature films. She has sung several popular songs for composers Harris Jayaraj, Yuvan Shankar Raja, Devi Sri Prasad and G. V. Prakash Kumar and has also received nominations at Filmfare and Vijay Awards for a few of them. She considers the song "Maalai Neram" as the most challenging she has sung.

She signed for Selvaraghavan's fantasy-adventure film Aayirathil Oruvan, which released in early 2010. In 2011, she agreed to play a minor supporting role in Venkat Prabhu's multi-starrer Mankatha, which was released in August 2011. In 2013, she made her debut in Malayalam cinema with Rajeev Ravi's romance film Annayum Rasoolum. She has rated this film as the best in her career. She played a role in Kamal Haasan's Vishwaroopam and will reprise the role in its sequel, which is to release in 2018.

Jeremiah was born in an Anglo-Indian Roman Catholic family in Arakkonam, Tamil Nadu, then moved to Chennai. Her father is a Lawyer at the High Court in Chennai. She has one younger sister who lives and works at Leuven, Belgium as a research assistant. Jeremiah was raised near Chennai and went to National Public School and graduated from Women's Christian College. She has said that she was quite a geek and wanted to be a Psychiatrist until she completed her 12th board exams.

In 2015, Jeremiah was cast alongside Mohanlal in Loham, directed by Ranjith. This was her third Malayalam film, and the first with Mohanlal.