Dosunmu made his directorial debut with a music video for Isaac Hayes in 1996. He went on to direct music videos for many other artists including Angie Stone, Common, Wyclef Jean, Kelis, Aaron Neville, Maxwell, Tracy Chapman and Talib Kweli. His 1999 documentary "Hot Irons", won best documentary at FESPACO. Dosunmu has directed episodes of a widely acclaimed South African television series Yizo, Yizo, which dramatizes the policy debates around education at a Johannesburg high school in post-apartheid South Africa. In 2010, in a lead up to the first ever World Cup in Africa, Dosunmu produced another documentary, The African Game, in which he explores the game of football (soccer) in the continent and its relations to the African culture in all its diversity. His transition into feature films came in 2011 with the film Restless City, which premiered at the Sundance Film Festival to generally positive reviews.

Dosunmu started his career as a design assistant at the fashion house of Yves Saint Laurent. He later became a creative Director (serving in that position for album covers for such artists as Erykah Badu and Public Enemy) and a fashion Photographer, with his photographs appearing in various international magazines. In 2007, he was honored with the request to speak at the TED Global conference. Dosunmu has directed and photographed numerous commercials for print advertising & TV for companies such as AT&T, General Motors, Levi's, Giordano Jeans, Kenneth Cole, Buddy System for ABC, My Kind of Town for AMES, Soul Food for Showtime. Photographs from his documentary The African Game were published in a coffee-table book by powerHouse Books. Dosunmu was recently selected to participate in the photography exhibition Snap Judgments: New Positions in Contemporary Photography at the International Center of Photography. Dosunmu has been a contributing Photographer for publications like Vibe, Clam, Fader, Face, Paper, Interview, i-D, Vogue Hommes – France and Italy, Complex, and Ebony.

He is the Director of the 2011 drama film Restless City, which premiered at the 2011 Sundance Film Festival. His next film, 2013's Mother of George, also premiered at Sundance, and was the Closing Night selection for Maryland Film Festival 2013. Dosunmu currently lives between New York and Lagos, Nigeria.