Apsion is also known for her portrayals of Kirsty in My Good Friend, Beverly in The Lakes, Patricia Hillman in Coronation Street, and Mrs. Beech in Michelle Magorian's Goodnight Mister Tom. She has appeared in two separate episodes of Midsomer Murders, Death in Chorus and Dead Man's 11, as two different characters. She also played a part in the docu-drama about the Hillsborough Disaster, which aired in 1996 and told the story of the 1989 football tragedy. In 1989 she also plays on Ghostbusters 2. A small role where she predicts the end of the world . She has since featured in an episode of Lewis and played a small role in the first episode of the sitcom In with the Flynns. Most recently, she appeared in the BBC series The Village alongside her Shameless co-star Maxine Peake.

In 2001, she co-starred alongside Johnny Depp, Heather Graham and Robbie Coltrane in From Hell as Polly Nichols, the first known victim of Jack the Ripper. Other films she has appeared in include About a Boy, The War Zone, Lolita, This Year's Love and Ironclad.

Outside of acting, she has appeared as a guest panellist on Five's The Wright Stuff during 2008 and 2009.

In 2014, Apsion portrayed Annette Walker in an episode of the detective drama Suspects (TV series), and more recently she appeared in episodes of Call the Midwife as Violet Buckle (née Gee) and in episodes of Doc Martin as Jennifer Cardew.