Brianna Monique Garcia-Colace was born in San Diego, California and raised on a farm in Scottsdale, Arizona. She was born sixteen minutes after her twin sister, Nicole, to parents Jon Garcia and Kathy Colace. She is of Mexican and Italian descent. Keen soccer enthusiasts, she along with her sister played for the Scottsdale club in elementary school. She graduated from Chaparral High School in 2002. She then returned to San Diego for college, but relocated to Los Angeles a year later, where she worked as a waitress at the Mondrian Hotel while trying to find an agent.

She then started modeling, acting, and doing promotional work. She made her first national TV appearance on the Fox reality show Meet My Folks. Following this appearance, the Garcia twins were hired to be the World Cup Twins for Budweiser and were photographed holding the World Cup trophy. Brie and her sister Nikki were contestants in the 2006 "International Body Doubles twins search". Brie and Nikki later participated in the 2006 WWE Diva Search, but they did not make the cut.

Starting in December 2007, they managed Derrick Linkin, but this storyline was cut short when Linkin was released in January 2008. They then resumed their feud with Neidhart and Crawford, wrestling them throughout much of 2008. After Neidhart was called up to the WWE roster in April 2008, Milena Roucka took her place in the feud. The twins also competed in bikini contests, and wrestled against other competitors including Katie Lea Burchill and Daisy. Their last FCW appearance was on September 2, when they competed in a Divas battle royal won by Miss Angela.

On the August 29, 2008 episode of SmackDown, Brianna debuted as Brie Bella and defeated Victoria. She quickly began a scripted rivalry with Victoria and Victoria's accomplice, Natalya, and had a series of matches against them. In each match, Brie would roll out of the ring and go underneath it, emerging and appearing revived, and then win the match. On the October 31 episode of SmackDown, when Brie went under the ring Victoria grabbed her legs, but a second pair of legs kicked her off, implying that a second person was under the ring. The following week on SmackDown, Brie picked up a win against Victoria and then ran under the ring to escape Natalya and Victoria, but Victoria and Natalya both reached for Brie under the ring, resulting in both Nicole and Brie being pulled out. The twins then attacked them and celebrated afterward. Nicole was then introduced as Nikki Bella. The twins had their first official match as a team on the November 21 episode of SmackDown, defeating Victoria and Natalya. They continued competing in tag team matches over the following months.

On June 29, 2009, they were both traded to the ECW brand. They returned to ECW the following night on The Abraham Washington Show, as the special guests. They quickly developed a storyline feud with Katie Lea Burchill, when Nikki defeated her in a match by switching places with Brie behind the referee's back. The following week on Superstars, Brie defeated Burchill after a similar fashion, and the feud ended in September, when Nikki defeated Burchill on Superstars.

The Bella Twins have appeared in nine WWE video games. They made their in-game debut at WWE SmackDown vs. Raw 2010 and appeared in WWE SmackDown vs. Raw 2011, WWE '12 (DLC), WWE '13, WWE 2K14 (DLC), WWE 2K15, WWE 2K16, WWE 2K17 and WWE 2K18.

On August 31, The Bella Twins announced they would be part of the all-female third season of NXT, mentoring Jamie. Jamie was the first rookie Diva eliminated on the October 5 episode of NXT. In November, the twins began a storyline with Daniel Bryan, when Brie accompanied him to the ring for his match. Following his win, Nikki ran out and the two fought over Bryan's affection, until Bryan broke it up and had them hug each other. They began to manage Bryan and frequently accompanied him to the ring over the next two months. In January 2011, both Bellas turned into villainous characters, when they discovered Bryan kissing Gail Kim backstage and assaulted her. They continued to attack Kim, both at the Royal Rumble and on Raw, and on February 7, they teamed with Melina in a losing effort to Kim, Eve Torres, and Tamina.

On May 1, 2012, the twins appeared at their first independent wrestling show in Newburgh, New York at Northeast Wrestling. They later appeared for CTWE Pro Wrestling at the Season Beatings pay-per-view on December 15, each accompanying a different Wrestler to the ring.

Both twins appeared on the WWE YouTube show The JBL & Cole Show. Nikki appeared at the Miss USA 2013 pageant as one of the Celebrity judges. They appeared at the 2014 MTV Europe Music Awards, where they presented the award for Best Female. The twins were both nominated for Choice Female Athlete at the 2015 Teen Choice Awards. Brie appeared alongside Paige, Natalya and the Chrisley family on the 88th Academy Awards edition of E! Countdown to the Red Carpet in February 2016. In 2016, Brie and Nikki were voted as Choice Female Athletes for the 2016 Teen Choice Awards.

Bella was previously in a relationship with former Poison Guitarist Richie Kotzen. In September 2013, she revealed her engagement to fellow professional Wrestler Bryan Danielson. The couple married on April 11, 2014. On October 5, 2016, Bella announced that the couple were expecting their first child due in April 2017. Bella gave birth to a baby girl on May 9, 2017, named Birdie Joe Danielson.

Nikki received her title match against AJ Lee on November 23 at Survivor Series, which she won, with Brie's help, to become a two-time Divas Champion. The duo had reconciled at this point, with Brie also turning heel in the process. Nikki then went on to retain her championship in three separate occasions – against Lee in a rematch on December 14, at TLC: Tables, Ladders and Chairs, against Naomi two days later on SmackDown, and against Paige at Fastlane on February 22, 2015. Paige and AJ then formed an alliance against the Bellas which led to a tag team match at WrestleMania 31, where AJ and Paige were victorious.

On November 21, 2016, Brie and Nikki unveiled their new YouTube channel, "The Bella Twins.” The sisters’ channel features daily fashion, beauty, travel, fitness, relationship, and health videos, along with daily video blogs, created by the twins themselves.

The Bella Twins appeared in YouTuber iiSuperwomanii's video "When Someone Tries to Steal Your BFF" on March 2, 2017.

The Bella Twins returned for the 25th anniversary of Raw on January 22, 2018. Brie later returned to in-ring competition at Royal Rumble, entering at number 28 in the first ever women's Royal Rumble match, one number after her sister Nikki, who would eliminate her from the match minutes later.