Langton made her television debut in 1992, appearing in several episodes of Beverly Hills, 90210, Freshman Dorm, and Baywatch. She later made her feature film debut as a drug addict in the 1994 action film Terminal Velocity. The following year, Langton was a regular cast member in the short-lived ABC adventure drama series, Extreme co-starring opposite James Brolin. Later that year, she played the lead role in the made-for-television movie, Eye of the Stalker.

In 1996, Langton joined the cast of the Fox prime time soap opera, Melrose Place, playing Samantha Reilly Campbell. She starred in the show during its fifth and sixth season, leaving early in the seventh season. After leaving Melrose Place, Langton was cast as lead in the USA Network series, The Net, a television drama based on the 1995 film of the same name. Langton portrayed the character Angela Bennett, who was played by Sandra Bullock in the film. The series was canceled after one season. She later starred alongside Keanu Reeves and Gene Hackman in the 2000 film The Replacements, her biggest feature credit to date. Langton also co-starred in the comedy films Playing Mona Lisa (2000), and Kiss the Bride (2002).

In 2001, Langton had the leading role in the Fox crime drama series, Fling, but the show was cancelled by the network before its premiere. During her later career, she starred in a number of smaller films, including Partner(s) (2005) with Jay Harrington and Julie Bowen, and Beautiful Dreamer alongside Colin Egglesfield. In 2007, she starred in the horror film Primeval opposite Dominic Purcell. From 2007 to 2008, she had a recurring role in the NBC drama series, Friday Night Lights. During that same time she co-starred as Charlie Crews attorney Constance Griffiths in another NBC drama, Life. In later years, Langton guest starred on The Closer, Bones, and Supernatural.

In 2015, she appeared in Oliver's Deal (2015) starring Stephen Dorff.