In March 2006, Carmen & Camille released their début album, Two, on their own label, TwinSpin Music. Several songs from this record were featured on the MTV reality show series The Hills, giving the sisters' music widespread exposure for the first time. Their 2009 single "Shine 4U," co-written with Producer Ryan Stewart, won the CHUM Emerging Artist Initiative. Consequently, the song enjoyed national airplay across Canada, and the music video was televised on MuchMusic. In March 2010, "Shine 4U" received additional recognition as a nominee for the 2010 Juno Award for Dance Recording of the Year. Carmen and Camille have sung the Canadian National Anthem at several games for the Canucks hockey team.

Carmen & Camille divide their time between Vancouver and Los Angeles, where they set up residence in December 2009.

The sisters were raised in White Rock, British Columbia and graduated from Semiahmoo Secondary School in nearby Surrey. Their father, John Thomas, currently serves as their professional manager. Carmen holds an Associate of Arts degree in broadcast journalism from the British Columbia Institute of Technology. She appeared as a host on Tommy Wolski’s Sport of Kings, a weekly Citytv Sports news show on horse racing. Camille, who began her studies in fashion design, later transferred to Vancouver Community College, where she completed the jazz vocal program.