Her films included Frank Borzage's I've Always Loved You (1946), Courage of Lassie (1946), The Fabulous Texan (1947), Borzage's That's My Man (1947), Old Los Angeles (1948), My Wife's Best Friend (1952), A Blueprint for Murder (1953), william Witney's The Outcast (1954), Ride the Wild Surf (1964), and Lipstick (1976).

McLeod married Bill Gerds (30 January 1947 - 1949) (divorced), who was then a dental student in San Francisco. They eloped to Reno on January 3, 1947. McLeod's second husband was actor Don Keefer, 7 May 1950 until her death on 11 March 1997 having 3 children together.

McLeod made two guest appearances on Perry Mason: Lorraine Ferrell in "The Case of the Vagabond Vixen," (1957), and Nora Huxley in "The Case of the Glittering Goldfish." (1959) In both roles she played the wife of the murder victim, but was neither the defendant nor actual murderer.

McLeod appeared in dozens of other series including The Millionaire, Meet McGraw, Richard Diamond, Private Detective, 77 Sunset Strip, Mickey Spillane's Mike Hammer, Bronco, Colt .45, Lawman (in the 1961 episode "The Prodigal Mother", with child actor Billy Booth), Bonanza, Hazel, Hawaiian Eye, Have Gun - Will Travel, The Outer Limits, The Virginian, "Letty, Gunsmoke" and the Ten Thousand Horses Singing episode of Studio One opposite James Dean and John Forsythe.

McLeod's greatest impact upon American consciousness by far, however, was as purveyor of one of the most ubiquitous catchphrases of its era when she portrayed the woman in the 1963 headache remedy Anacin television commercial who plaintively but irritably said, "Mother, please! I'd rather do it myself!" The announcer's voiceover would then intone, "Sure you have a headache... tense, irritable.... but don't take it out on her."