During this time period, Marker began to travel around the world as a Journalist and Photographer, a vocation he would continue the rest of his life. He was hired by the French publishing company Éditions du Seuil as Editor of the series Petite Planète ("Small World"). This collection devoted one edition to each country and included information and photographs. In 1949 Marker published his first novel, Le Coeur net (The Forthright Spirit), which was about aviation. In 1952 Marker published an illustrated essay on French Writer Jean Giraudoux, Giraudoux Par Lui-Même.

During his early journalism career, Marker became increasingly interested in filmmaking and experimented with photography in the early 1950s. Around this time Marker met and befriended many members of what would be called the Left Bank Film Movement, including Alain Resnais, Agnès Varda, Henri Colpi, Armand Gatti and the novelists Marguerite Duras and Jean Cayrol. This group is often associated with the French New Wave Directors who came to prominence during the same time period, and indeed both groups were often friends and journalistic co-workers. The term Left Bank was first coined by film critic Richard Roud, who has described them as having "fondness for a kind of Bohemian life and an impatience with the conformity of the Right Bank, a high degree of involvement in literature and the plastic arts, and a consequent interest in experimental filmmaking", as well as an identification with the political left. Many of Marker's earliest films were produced by Anatole Dauman.

In 1952 Marker made his first film, Olympia 52, a 16mm feature documentary about the 1952 Helsinki Olympic Games. In 1953 Marker collaborated with Resnais on the documentary Statues Also Die. The film examines traditional African art such as sculptures and masks, and its decline with coming of Western colonialism. The film won the 1954 Prix Jean Vigo, but was banned by French censors for its criticism of French colonialism.

After working as assistant Director on Resnais's Night and Fog in 1955, Marker made Sunday in Peking, a short documentary "film essay" that would characterize Marker's unique film style for most of his career. The film was shot in two weeks by Marker while he was traveling through China with Armand Gatti in September 1955. In the film, Marker's commentary overlaps scenes from China, such as tombs which, contrary to Westernized understandings of Chinese legends, do not contain the remains of any Ming Dynasty emperors.

After working on the commentary for Resnais' film Le mystère de l'atelier quinze in 1957, Marker continued to form his own cinematic style with the feature documentary Letter from Siberia. An essay film on the narrativization of Siberia, it contains Marker's signature commentary, which takes the form of a letter from the Director, in the long tradition of epistolary treatments by French explorers of the "undeveloped" world. Letter looks at the modernization of Siberia with its movement into the twentieth century, but with a look back at some of the tribal cultural practices now receding into the past. It combines footage that Marker shot in Siberia with old newsreel footage, cartoon sequences, stills, and even an illustration of Alfred E. Neuman from Mad Magazine as well as a fake TV commercial as part of a humorous attack on Western mass culture. In producing a meta-commentary on narrativity and film, Marker uses the same brief filmic sequence three times but with different commentary—the first one praising the Soviet Union, the second denouncing it, and the third taking an apparently neutral or "objective" stance.

In 1959 Marker made the animated film Les Astronautes with Walerian Borowczyk. The film was a combination of traditional drawings with still photography. In 1960 Marker made Description d'un combat, a documentary on the State of Israel which reflects on the country's past and Future. The film won the Golden Bear for Best Documentary at the 1961 Berlin Film Festival.

In January 1961, Marker traveled to Cuba and shot the film ¡Cuba Sí! The film promotes and defends Fidel Castro and includes two interviews with the Comandante. The film ends with an anti-American epilogue in which the United States is embarrassed by the Bay of Pigs Invasion fiasco, and was subsequently banned. The banned essay was included in Marker's first volume of collected film commentaries, Commentaires I, published in 1961. The following year Marker published Coréennes, a collection of photographs and essays on the conditions of Korea.

Marker became known internationally for the short film La Jetée (The Pier) in 1962. It tells of a post-nuclear war experiment in time travel by using a series of filmed photographs developed as a photomontage of varying pace, with limited narration and sound effects. In the film, a survivor of a Futuristic third World War is obsessed with distant and disconnected memories of a pier at the Orly Airport, the image of a mysterious woman, and a man's death. Scientists experimenting in time travel choose him for their studies, and the man travels back in time to contact the mysterious woman, and discovers that the man's death at the Orly Airport was his own. Except for one shot of the woman mentioned above sleeping and suddenly waking up, the film is composed entirely of photographs by Jean Chiabaud and stars Davos Hanich as the man, Hélène Chatelain as the woman and filmmaker william Klein as a man from the Future.

While making La Jetee, Marker was simultaneously making the 150-minute documentary essay-film Le joli mai, released in 1963. Beginning in the Spring of 1962, Marker and his camera operator Pierre Lhomme shot 55 hours of footage interviewing random people on the streets of Paris. The questions, asked by the unseen Marker, range from their personal lives, as well as social and political issues of relevance at that time. As he had with montages of landscapes and indigenous art, Marker created a film essay that contrasted and juxtaposeed a variety of lives with his signature commentary (spoken by Marker's friends, singer-actor Yves Montand in the French version and Simone Signoret in the English version). The film has been compared to the Cinéma vérité films of Jean Rouch, and criticized by its practitioners at the time. The term "Cinéma vérité" was itself anathema to Marker; he would never use it. It was shown in competition at the 1963 Venice Film Festival, where it won the award for Best First Work. It also won the Golden Dove Award at the Leipzig DOK Festival.

After the documentary Le Mystère Koumiko in 1965, Marker made Si j'avais quatre dromadaires, an essay-film that, like La jetée, is a photomontage of over 800 photographs that Marker had taken over the past 10 years from 26 countries. The commentary takes on a slightly different dimension from his previous commentaries by using a conversation between a fictitious Photographer and two friends, who discuss the photos. The film's title is an allusion to a poem by Guillaume Apollinaire. It was the last film in which Marker included "travel footage" for many years.

In 1967 Marker published his second volume of collected film essays, Commentaires II. That same year, Marker organized the omnibus film Loin du Vietnam, a protest against the Vietnam War with segments contributed by Marker, Jean-Luc Godard, Alain Resnais, Agnès Varda, Claude Lelouch, william Klein, Michele Ray and Joris Ivens. The film includes footage of the war, from both sides, as well as anti-war protests in New York and Paris and other anti-war activities.

The film was intended to be an all-encompassing portrait of political movements since May 1968, a summation of the work which he had taken part in for ten years. The film is divided into two parts: the first half focuses on the hopes and idealism before May 1968, and the second half on the disillusion and disappointments since those events. Marker begins the film with the Odessa Steps sequence from Sergei Eisenstein's film The Battleship Potemkin, which Marker points out is a fictitious creation of Eisenstein which has still influenced the image of the historical event. Marker used very little commentary in this film, but the film's montage structure and preoccupation with memory make it a Marker film. Upon release, the film was criticized for not addressing many current issues of the New Left such as the woman's movement, sexual liberation and worker self-management. The film was re-released in the US in 2002.

In the late 1970s, Marker traveled extensively throughout the world, including an extended period in Japan. From this inspiration, he first published the photo-essay Le Dépays in 1982, and then used the experience for his next film Sans Soleil, released in 1982.

Marker had been working on a film about Chile with ISKRA since 1973. Marker had collaborated with Belgian Sociologist Armand Mattelart and ISKRA members Valérie Mayoux and Jacqueline Meppiel to shoot and collect the visual materials, which Marker then edited together and provided the commentary for. The resulting film was the two and a half-hour documentary La Spirale, released in 1975. The film chronicles events in Chile, beginning with the 1970 election of socialist President Salvador Allende until his murder and the resulting coup in 1973.

In 1974 returned to his personal work and made a film outside of ISKRA. La Solitude du chanteur de fond is a one-hour documentary about Marker's friend Yves Montand's benefit concert for Chilean refugees. The concert was Montand's first public performance in four years, and the documentary includes film clips from his long career as a singer and actor.

Marker then began work on one of his most ambitious films, A Grin Without a Cat, released in 1977. The film's title refers to the Cheshire Cat from Alice in Wonderland. The metaphor compares the promise of the global socialist movement before May 1968 (the grin) with its actual presence in the world after May 1968 (the cat). The film's original French title is Le fond de l'air est rouge, which means "the air is essentially red", or "revolution is in the air", implying that the socialist movement was everywhere around the world.

Sans Soleil stretches the limits of what could be called a documentary. It is an essay, a montage, mixing pieces of documentary with fiction and philosophical comments, creating an atmosphere of dream and science fiction. The main themes are Japan, Africa, memory and travel. A sequence in the middle of the film takes place in San Francisco, and heavily references Alfred Hitchcock's Vertigo. Marker has said that Vertigo is the only film "capable of portraying impossible memory, insane memory." The film's commentary are credited to the fictitious cameraman Sandor Krasna, and read in the form of letters by an unnamed woman. Though centered around Japan, the film was also shot in such other countries as Guinea Bissau, Ireland and Iceland. Sans Soleil was shown at the 1983 Berlin Film Festival where it won the OCIC Award. It was also awarded the Sutherland Trophy at the 1983 British Film Institute Awards.

In 1984, Marker was invited by Producer Serge Silberman to document the making of Akira Kurosawa's film Ran. From this Marker made A.K., released in 1985. The film focuses more on Kurosawa's remote but polite personality than on the making of the film. The film was screened in the Un Certain Regard section at the 1985 Cannes Film Festival, before Ran itself had been released.

In 1985, Marker's long-time friend and neighbor Simone Signoret died of cancer. Marker then made the one-hour TV documentary Mémoires pour Simone as a tribute to her in 1986.

La Jetée was the inspiration for Mamoru Oshii's 1987 debut live action feature The Red Spectacles (and later for parts of Oshii's 2001 film Avalon as well) and also inspired Terry Gilliam's 12 Monkeys (1995). It also inspired many of Director Mira Nair's shots for the 2006 film The Namesake.

Beginning with Sans Soleil, he developed a deep interest in digital Technology, which led to his film Level Five (1996) and Immemory (1998, 2008), an interactive multimedia CD-ROM, produced for the Centre Pompidou (French language version) and from Exact Change (English version). Marker created a 19-minute multimedia piece in 2005 for the Museum of Modern Art in New York City titled Owls at Noon Prelude: The Hollow Men which was influenced by T. S. Eliot's poem.

Marker lived in Paris, and very rarely granted interviews. One exception was a lengthy interview with Libération in 2003 in which he explained his approach to filmmaking. When asked for a picture of himself, he usually offered a photograph of a cat instead. (Marker was represented in Agnes Varda's 2008 documentary The Beaches of Agnes by a cartoon drawing of a cat, speaking in a technologically altered voice.) Marker's own cat was named Guillaume-en-égypte. In 2009, Marker commissioned an Avatar of Guillaume-en-Egypte to represent him in machinima works. The avatar was created by Exosius Woolley and first appeared in the short film / machinima, Ouvroir the Movie by Chris Marker.

From 2007 through 2011 Chris Marker had collaborated with the art dealer and publisher Peter Blum on a variety of projects which were exhibited at the Peter Blum galleries in the SoHo and Chelsea neighborhoods. Marker's works have also been exhibited at the current Peter Blum Gallery location in the Midtown neighborhood on 57th Street in the year of 2014. These projects include several series of printed photographs titled PASSENGERS, Koreans, Crush Art, Quelle heure est-elle?, and Staring Back; a set of photogravures titled After Dürer; a book titled PASSENGERS; and digital prints of movie posters, whose titles were often appropriated, titled Breathless, Hiroshima Mon Amour, Owl People, and Rin Tin Tin. The video installations titled Silent Movie and Owls at Noon Prelude: The Hollow Men were exhibited through Peter Blum in 2009. These mentioned works have also been exhibited at the 2014 & 2015 Venice Biennale, Whitechapel Gallery in London, the MIT List Visual Arts Center in Cambridge, Massachusetts, the Carpenter Center for the Visual Arts at Harvard University in Cambridge, Massachusetts, the Moscow Photobiennale, Les Recontres d'Arles de la Photographie in Arles, France, the Centre de la Photographie in Geneva, Switzerland, the Walker Art Center in Minneapolis, Minnesota, the Wexner Center for the Arts in Columbus, Ohio, The Museum of Modern Art in New York, and the Pacific Film Archive in Berkeley, California. Since 2014 the artworks of the Estate of Chris Marker are represented by Peter Blum Gallery, New York.

Marker died on 29 July 2012, 91 years to the day after his birth.