Van Vuuren's first quarantine period began when he started coughing up blood and an x-ray revealed a hole in his lung: he was admitted to hospital on 9 December 2009 and placed in isolation on 11 December 2009. This first period of quarantine ended on 2 January 2010. Van Vuuren was re-admitted on 18 January 2010 when his tuberculosis proved resistant to medication. He was finally released from quarantine on 28 June 2010 after producing videos about his experience in isolation. His videos recorded as The Fully Sick Rapper while quarantined received over one million hits and led to the World Health Organization (WHO) contacting him to help promote World Tuberculosis Day. As of April 2010, his Facebook page had attracted over 14,000 likes.

In September 2010 Van Vuuren participated in the "30 Days Has September" initiative of The Ted Noffs Foundation Inc. During each day of September 2010, he recorded "new activities, experiences and mischief making" in order to raise money for the foundation.

In 2014, Van Vuuren starred with Nicholas Boshier in the ABC2 television series Soul Mates; the two had previously collaborated on the web series Bondi Hipsters. In September 2014 Van Vuuren was featured in an episode of the Australian Story documentary series, and in 2016 he appeared in the miniseries Stag.