She studied at the Conservatoire National Supérieur d'Art Dramatique (CNSAD) in Paris, during this time she made several plays. Her first work out of the theater was at the 1999 short film Dieu, que la nature est bien faite!. While she was acting on a play in Paris she was noticed by Jérôme Bonnel that she was cast in her first film Le Chignon d'Olga in 2002.

In 2005 she starred alongside Louis Garrel in Philippe Garrel's Regular Lovers, it was her first main role at the cinema. After the film she starred the short film Comment on freine dans une descente? in 2006.

In 2007 she starred for the second time a film with Louis Garrel, in this time Christophe Honoré's Love Songs, a role that earned her the 2008 SACD Awards for Female Revelation and a César Awards nomination for Most Promising Actress. Also in 2008 she was nominated for a Molière Award for her performance in Marivaux's La Seconde Surprise de l'amour.

In 2009 she made an appearance in Christophe Honoré's The Beautiful Person. In 2010 she appeared in one of the main roles of the Portuguese film, directed by the Chilean Raúl Ruiz in his last work, Mysteries of Lisbon alongside an international cast.

In 2011 starred the French film Angèle et Tony and won for the role of Angèle a César Award for Most Promising Actress. In 2012 starred Three Worlds directed by Catherine Corsini, the film competed in the Un Certain Regard section at the 2012 Cannes Film Festival.

Also in 2012 she starred in Les Revenants, a TV series that is considered an international success by critics and audiences.