Destiny's Child were compared to The Supremes, a 1960s American female singing group, with Knowles being compared to Supremes frontwoman Diana Ross; Knowles, however, has dismissed the notion. Coincidentally, Knowles starred in the film adaptation of the 1981 Broadway musical Dreamgirls as Deena Jones, the front woman of the Dreams, a female singing group based on the Supremes. With Knowles' wide role assumed in the production of Survivor, Gil Kaufman of MTV noted that "it became clear that Beyoncé was emerging as DC's unequivocal musical leader and public face". Her dominance to the creative input in the album made the album "very much her work". For Lola Ogunnaike of The New York Times, "It's been a long-held belief in the music industry that Destiny's Child was little more than a launching pad for Beyoncé Knowles' inevitable solo career."

In 1990, Beyoncé Knowles met Rapper LaTavia Roberson while auditioning for a girl group. Based in Houston, Texas, they were joined to a group that performed rapping and dancing. Kelly Rowland, who relocated to Knowles' house because of family issues, joined them in 1992. Originally named Girl's Tyme, they were eventually cut down to six members including Támar Davis and sisters Nikki and Nina Taylor. With Knowles and Rowland, Girl's Tyme attracted nationwide attention: west-coast R&B Producer Arne Frager flew to Houston to see them. He brought them to his studio, The Plant Recording Studios, in Northern California, with focus on Knowles' vocals because Frager thought she had personality and the ability to sing. With efforts to sign Girl's Tyme to a major record deal, Frager's strategy was to debut the group in Star Search, the biggest talent show on national TV at the time. However, they lost the competition because, according to Knowles, their choice of song was wrong; they were actually rapping instead of singing.

Because of the group's defeat, Knowles' father, Mathew, voluntarily dedicated his time to manage them. Mathew Knowles decided to cut the original lineup to four, with the removal of Davis and the Taylor sisters and the inclusion of LeToya Luckett in 1993. Aside from spending time at their church in Houston, Girl's Tyme practiced in their backyards and at Headliners Salon, owned by Knowles' mother, Tina. The group would test routines in the salon, when it was on Montrose Boulevard in Houston, and sometimes would collect tips from the customers. Their try out would be critiqued by the people inside. During their school days, Girl's Tyme performed at local gigs. When summer came, Mathew Knowles established a "boot camp" to train them in dance and vocal lessons. After rigorous training, they began performing as opening acts for established R&B groups of that time such as SWV, Dru Hill and Immature. Tina Knowles designed the group's attire for their performances.

Over the course of the early years in their career, Girl's Tyme changed their name to Something Fresh, Cliché, the Dolls, and to Destiny. The group signed with Elektra Records with the name Destiny, but were dropped several months later before they could release an album. The pursuit of a record deal affected the Knowles family: in 1995, Mathew Knowles resigned from his job as a medical-equipment salesman, a move that reduced Knowles' family's income by half, and her parents briefly separated due to the pressure. In 1996, they changed their name to Destiny's Child, which was taken from a passage in the Book of Isaiah. Mathew Knowles helped in negotiating a record deal with Columbia Records, which signed the group that same year. Prior to signing with Columbia, the group had recorded several tracks in Oakland, California produced by D'wayne Wiggins of Tony! Toni! Toné!, including "Killing Time", which upon the label's recognition that Destiny's Child had a "unique quality", was included in the Soundtrack to the 1997 film Men in Black.

Destiny's Child released their self-titled debut album in the United States on February 17, 1998, featuring productions by Tim & Bob, Rob Fusari, Jermaine Dupri, Wyclef Jean, Dwayne Wiggins and Corey Rooney. Destiny's Child peaked at number sixty-seven on the Billboard 200 and number fourteen on the Billboard Top R&B/Hip-Hop Albums. It managed to sell over one million copies in the United States, earning a platinum certification by the Recording Industry Association of America (RIAA). The remix version to the album's lead single, "No, No, No", reached number one on the Billboard Hot R&B/Hip-Hop Singles & Tracks and number three on the Billboard Hot 100. Its follow-up single, "With Me Part 1" failed to reproduce the success of "No, No, No". Meanwhile, the group featured on a song from the Soundtrack album of the romantic drama Why Do Fools Fall in Love and "Get on the Bus" had a limited release in Europe and other markets. In 1998, Destiny's Child garnered three Soul Train Lady of Soul awards including Best New Artist for "No, No, No". Knowles considered their debut successful but not huge, claiming as a neo soul record it was too mature for the group at the time.

In December 1999, Luckett and Roberson attempted to split with their manager, claiming that he kept a disproportionate share of the group's profits and unfairly favored Knowles and Rowland. While they never intended to leave the group, when the video for "Say My Name" surfaced in February 2000, Roberson and Luckett found out that two new members were joining Knowles and Rowland. Prior to the video premiere, Knowles announced on TRL that original members Luckett and Roberson had left the group. They were replaced by Michelle Williams, a former backup singer to Monica, and Farrah Franklin, an aspiring singer-actress. Shortly after her stint with Monica, Williams was introduced to Destiny's Child by Choreographer Braden Larson aka "Peanut Orlando", and was flown to Houston where she stayed with the Knowles family.

Destiny's Child's final line-up as a trio has been widely noted as the group's most recognizable and successful line-up. Billboard recognized them as one of the greatest musical trios of all time; they were also ranked as the third most successful girl group of all time on the Billboard charts, behind TLC and The Supremes. The group's single "Independent Women" (2000) ranked second on Billboard's list of the "Top 40 Biggest Girl Group Songs of All Time on the Billboard Hot 100 Chart". "Independent Women" was also acknowledged by the Guinness World Records as the longest-running number-one song on the Hot 100 by a girl group. The term "Bootylicious" (a combination of the words booty and delicious) became popularized by Destiny's Child's single of the same and was later added to the Oxford English Dictionary in 2006. The term was also used to describe Beyoncé during the 2000s decade due to her curvacious figure. VH1 included "Bootylicious" on their "100 Greatest Songs of the '00s" list in 2011, and Destiny's Child on their "100 Greatest Women in Music" list the following year. Additionally, "Independent Women" was ranked as one of NME's "100 Best Songs of the 00s". Destiny's Child was honored at the 2005 World Music Awards with the World's Best Selling Female Group of All Time Award, which included a 17-minute tribute performance by Patti LaBelle, Usher, Babyface, Rihanna, Amerie and Teairra Mari. In 2006, the group was awarded a star on the Hollywood Walk of Fame.

Destiny's Child recorded R&B songs with styles that encompasses urban, contemporary, and dance-pop. In the group's original line-up, Knowles was the lead vocalist, Rowland was the second lead vocalist, Luckett was on Soprano, and Roberson was on alto. Knowles remained as the lead vocalist in the group's final line-up as a trio, however, Rowland and Williams also took turns in singing lead for the majority of their songs. Destiny's Child cited R&B singer Janet Jackson as one of their influences. Ann Powers of The New York Times described Destiny's Child music as "fresh and emotional ... these ladies have the best mixes, the savviest samples and especially the most happening beats." In the same publication, Jon Pareles noted that the sound that defines Destiny's Child, aside from Knowles' voice, "is the way its melodies jump in and out of double-time. Above brittle, syncopated rhythm tracks, quickly articulated verses alternate with smoother choruses." The group usually Harmonize their vocals in their songs, especially on the ballads. In most instances of their songs, each member sings one verse and chimes in at the chorus. In their third album Survivor (2001), each member sings lead in the majority of the songs. Knowles said, "... everybody is a part of the music ... Everybody is singing lead on every song, and it's so great—because now Destiny's Child is at the point vocally and mentally that it should be at." Knowles, however, completely led songs like "Brown Eyes" and "Dangerously in Love". The group explored their lyrics to man-to-woman relationship, sisterhood and female empowerment anthems.

D'wayne Wiggins, who had produced their first recordings as Destiny's Child, filed suit in 2002 against his former counsel (Bloom, Hergott, Diemer & Cook LLP) seeking $15 million in damages for lessening his contractual agreement with the group without his consent, effectively nullifying his original contract that offered Sony Music/Columbia Destiny's Child's exclusive recording services for an initial seven years, in exchange for "certain royalties", instead of royalties only from the first three albums. The case was settled for an undisclosed amount. In June 2003, Mathew Knowles announced that Destiny's Child would expand back to a quartet, revealing Knowles' younger sister, Solange, as the latest addition to the group. Destiny's Child had previously recorded songs with Solange and shared the stage when she temporarily replaced Rowland after she broke her toes while performing. Their manager, however, said the idea was used to test reactions from the public. In August 2003, Knowles herself confirmed that her sister would not be joining in the group, and instead promoted Solange's debut album, Solo Star, released in January 2003.

In the wake of Knowles' debut solo album Dangerously in Love (2003), rumors spread about a possible split of Destiny's Child after each member had experienced solo success and had ongoing projects. Comparisons were drawn to Justin Timberlake, who did not return to band NSYNC after his breakthrough debut solo album, Justified. Rowland responded to such rumors, announcing they were back in the studio together. The group claimed that the reunion was destined to happen and that their affinity to each other kept them cohesive. Margeaux Watson, arts Editor at Suede magazine, suggested that Knowles "does not want to appear disloyal to her former partners," and called her decision to return to the group "a charitable one". Knowles' mother, Tina, wrote a 2002-published book, titled Destiny's Style: Bootylicious Fashion, Beauty and Lifestyle Secrets From Destiny's Child, an account of how fashion influenced Destiny's Child's success.

Survivor contains themes interpreted by the public as a reference to the group's internal conflict. The title track, "Survivor", which set the theme used throughout the album, features the lyrics "I'm not gonna blast you on the radio ... I'm not gonna lie on you or your family ... I'm not gonna hate you in the magazine" caused Roberson and Luckett to file a lawsuit against the group; the lyrics were perceived to be a violation over their agreement following a settlement in court. In an interview, Knowles commented: "The lyrics to the single 'Survivor' are Destiny's Child's story, because we've been through a lot, ... We went through our drama with the members ... Any complications we've had in our 10-year period of time have made us closer and tighter and better." In another song called "Fancy", which contains the lyrics "You always tried to compete with me, girl ... find your own identity", was interpreted by critic David Browne, in his review of the album for Entertainment Weekly magazine, as a response to the lawsuit. Stephen Thomas Erlewine of AllMusic summarized Survivor as "a determined, bullheaded record, intent on proving Destiny's Child has artistic merit largely because the group survived internal strife. ... It's a record that tries to be a bold statement of purpose, but winds up feeling forced and artificial." Despite the album's receiving critical praise, Knowles' close involvement has occasionally generated criticism. Knowles wrote and co-produced the bulk of Survivor. Browne suggested that her help made Survivor a "premature, but inevitable, growing pains album". In the majority of the songs on their final studio album Destiny Fulfilled (2004), the verses are divided into three sections, with Knowles singing first, followed by Rowland, then Williams; the three Harmonize together during the choruses.

Destiny's Child released their greatest hits album, #1's, on October 25, 2005. The compilation includes their number-one hits including "Independent Woman Part 1", "Say My Name" and "Bootylicious". Three new tracks were recorded for the compilation including "Stand Up for Love", which was recorded for the theme song to the World Children's Day, and "Check on It", a song Knowles recorded for The Pink Panther's Soundtrack. Record Producer David Foster, his daughter Amy Foster-Gillies and Knowles wrote "Stand Up for Love" as the anthem to the World Children's Day, an annual worldwide event to raise awareness and funds for children causes. Over the past three years, more than $50 million have been raised to benefit Ronald McDonald House Charities and other children's organizations. Destiny's Child lent their voices and support as global ambassadors for the 2005 program. #1's was also released as a DualDisc, featuring the same track listing, seven videos of selected songs and a trailer of the concert DVD Destiny's Child: Live in Atlanta. The DVD was filmed during the Atlanta visit of the Destiny Fulfilled ... And Lovin' It tour, and was released on March 28, 2006. It has been certified platinum by the RIAA, denoting shipments of over one million units. The title of the compilation fueled a ripple as it contained number-one singles, although not exclusively. While the liner notes of the compilation does not present any information regarding commercial performances of the songs featured, Writer Keith Caulfield of Billboard magazine suggested that the name could only be "a marketing angle". Despite this, Journalist Chris Harris of MTV said that it "lives up to its name".

Destiny's Child reunited for a farewell performance at the 2006 NBA All-Star Game on February 19, 2006 in Houston, Texas; however, Knowles commented, "It's the last album, but it's not the last show." Their final televised performance was at the Fashion Rocks benefit concert in New York a few days later. On March 28, 2006, Destiny's Child was inducted into the Hollywood Walk of Fame, the 2,035th recipient of the coveted recognition. At the 2006 BET Awards, Destiny's Child won Best Group, a category they also earned in 2005 and 2001.

After their formal disbandment, all members resumed their solo careers and have each experienced different levels of success. Since then, Knowles, Rowland and Williams have continued to collaborate on each other's solo projects through song features, music video appearances, and live performances. Both Rowland and Williams, along with Knowles' sister Solange, appeared in Knowles' music video for her single "Get Me Bodied" (2007). On June 26, 2007, the group made a mini-reunion at the 2007 BET Awards, where Knowles performed "Get Me Bodied" with Williams and Solange as her back-up Dancers. After her performance, Knowles introduced Rowland who performed her single "Like This" (2007) with Eve. On the September 2, 2007 Los Angeles stop of The Beyoncé Experience tour, Knowles sang a snippet of "Survivor" with Rowland and Williams, and the latter two rendered a "Happy Birthday" song to Knowles. The performance was featured in Knowles' tour DVD, The Beyoncé Experience Live. In 2008, Knowles recorded a cover of Billy Joel's "Honesty" for Destiny's Child's compilation album Mathew Knowles & Music World Present Vol.1: Love Destiny, which was released only in Japan to celebrate the group's tenth anniversary.

Rowland made a cameo appearance in Knowles' music video for her single "Party" (2011), and the group's third compilation album, Playlist: The Very Best of Destiny's Child, was released in 2012 to mark the fifteenth anniversary since their formation. The fourth compilation album, Love Songs, was released on January 29, 2013, and included the newly recorded song "Nuclear", produced by Pharrell Williams. "Nuclear" marked the first original music from Destiny's Child in eight years. The following month, Rowland and Williams appeared as special guests for Knowles' Super Bowl XLVII halftime show, where they performed "Bootylicious", "Independent Women" and Knowles' own song "Single Ladies (Put a Ring on It)". A video album titled Destiny's Child Video Anthology was released in May 2013 and featured sixteen of the group's music videos. Knowles and Williams were then featured on Rowland's song "You Changed" from her fourth solo album Talk a Good Game (2013). Later that year, Rowland and Williams made cameo appearances in the music videos for Knowles' songs "Superpower" and "Grown Woman", which were both included on her self-titled fifth solo visual album. Williams released the single "Say Yes" in June 2014, featuring Knowles and Rowland. They performed "Say Yes" together during the 2015 Stellar Awards, and the live version of the song was mastered for iTunes in April 2015. On November 7, 2016, the group reunited in a video to try the Mannequin Challenge, which was posted on Rowland's official Instagram account.

Destiny's Child have been referred to as R&B icons, and have sold more than 60 million records worldwide. Following the disbandment of Destiny's Child, MTV's James Montgomery noted that "they have left a fairly sizable legacy behind" as "one of the best-selling female pop vocal groups in history." Billboard observed that Destiny's Child were "defined by a combination of feisty female empowerment anthems, killer dance moves and an eviable fashion sense," while Essence noted that they "set trends with their harmonious music and cutting-edge style." In 2015, Daisy Jones of Dazed Digital published an article on how the group made a significant impact in R&B music, writing "Without a hint of rose tint, Destiny's Child legitimately transformed the sound of R&B forever... their distinct influence can be found peppered all over today's pop landscape, from Tinashe to Ariana Grande." Nicole Marrow of The Cut magazine believed that R&B music in the 1990s and early 2000s "was virtually redefined by the success of powerhouse performers like TLC and Destiny's Child, who preached a powerful litany of embracing womanhood and celebrating individuality." Hugh McIntyre of Forbes wrote that before The Pussycat Dolls and Danity Kane burst onto the music scene in the mid-2000s, Destiny's Child were "the reigning queens" of the girl group genre.

Destiny's Child has been credited as a musical influence or inspiration by several artists including Rihanna, Meghan Trainor, Fifth Harmony, Little Mix, Girls Aloud, Haim, Jess Glynne, Katy B, and RichGirl. Ciara was inspired to pursue a career in music after seeing Destiny's Child perform on television. Ariana Grande cited Destiny's Child as one of her vocal inspirations, saying that listening to the group's music is how she discovered her range and "learned about harmonies and runs and ad-libs." Meghan Trainor stated that her single "No" (2016) was inspired by the late 1990s and early 2000s sounds of Destiny's Child, NSYNC, and Britney Spears. Fifth Harmony cited Destiny's Child as their biggest inspiration, and even paid tribute to the group by performing a medley of "Say My Name", "Independent Women", "Bootylicious" and "Survivor" on the television show Greatest Hits. Fifth Harmony also incorporated elements of the intro from "Bootylicious" for the intro to their own song "Brave, Honest, Beautiful" (2015).

The group reunited for Beyoncé's headline performance at Coachella 2018.