Bhise was cast in her first film, The Accidental Husband, directed by Griffin Dunne, in tenth grade. While in high school, she also directed a documentary film Hijras: The Third Gender, which won the award for Best Social Documentary at the New York Independent Film Festival in 2009. After graduating from Johns Hopkins, Bhise was cast in Partial Comfort’s Off-Broadway production of And Miles To Go, a play written by Chad Beckim, directed by Hal Brooks. She played small parts in television series such as Elementary and One Bad Choice until she was cast in The Man Who Knew Infinity with Dev Patel and Jeremy Irons. She will be seen next as the lead role in Swords and Sceptres, the upcoming biopic on Indian queen Rani Lakshmibai, acting opposite Derek Jacobi and Rupert Everett. Bhise also co-wrote the script.

Bhise is part of New York’s New Abolitionists, a group of New Yorkers "united by our commitment to ending human trafficking, in New York State and globally", alongside Christie Brinkley, Michael Bloomberg, Tina Fey, Seth Meyers, Lee Daniels, Preet Bharara, Diane von Furstenberg, Gloria Steinem, Meryl Streep, and others.