In 1985, she married Michael Lohan. The couple briefly separated in 1988, and later reunited. Dina filed for divorce in 2005, and the couple reached a divorce settlement in August 2007, with the divorce scheduled to be finalized three months later. He had worked as a Wall Street trader and businessman who inherited his father's pasta Business and has been in trouble with the law on several occasions. The Lohans have four children: Lindsay (b. 1986), Michael, Jr. (b. 1987), Aliana (b. 1993), and Dakota Lohan (b. 1996).

On August 5, 2008, Anderson Cooper appeared as a guest co-host on the ABC talk show Live with Regis and Kelly, during which he stated, in reference to Living Lohan, "I can't believe I'm wasting a minute of my life watching these horrific people. In an interview with OK! magazine, Dina Lohan responded, "people are just cruel...This is bad karma for him". Cooper did not respond directly to Lohan's comments, but clarified that while he felt bad for Ali Lohan, he opined that she should be living the conventional life of a teenager, and not be made to star in a reality television show. Michael Lohan also responded to Cooper's comments, telling Access Hollywood, "I think Anderson Cooper is an opinionated, hypocritical idiot who should be an adult and keep his opinion to himself...He is the last person to judge anyone, when he and his own family have their own issues."

Lohan was arrested for speeding and driving under the influence in Nassau County, Long Island on September 12, 2013, and agreed to a plea deal which included admitting guilt. She was sentenced to 100 hours community Service, had her drivers license revoked for one year, and was fined $3,000.