Dolores Costello has a star on the Hollywood Walk of Fame for her contributions to Motion Pictures, at 1645 Vine Street.

Dolores Costello appeared as a child Actress in many films made between 1909 and 1915 . Among them are:

She restarted her motion picture career in 1923 after spending several years modeling in New York.

Within a few years of achieving stardom, the delicately beautiful blonde-haired Actress had become a successful and highly regarded film personality in her own right. As a young adult her career developed to the degree that in 1926, she was named a WAMPAS Baby Star, and had acquired the nickname "The Goddess of the Silver Screen".

Warners alternated Costello between films with contemporary settings and elaborate costume dramas. In 1927, she was re-teamed with John Barrymore in When a Man Loves, an adaptation of Manon Lescaut. In 1928, she co-starred with George O'Brien in Noah's Ark, a part-talkie epic directed by Michael Curtiz.

Costello spoke with a lisp (something that her granddaughter, Drew Barrymore, seemingly inherited), and found it difficult to make the transition to talking pictures, but after two years of voice coaching she was comfortable speaking before a microphone. One of her early sound film appearances was with her sister Helene in Warner Bros.'s all-star extravaganza, The Show of Shows (1929).

Her acting career became less a priority for her following the birth of her first child, Dolores Ethel Mae "DeeDee" Barrymore, on April 8, 1930, and she retired from the screen in 1931 to devote time to her family. Her second child, John Drew Barrymore, was born on June 4, 1932, but the marriage proved difficult due to her husband's increasing alcoholism, and they divorced in 1935.

She resumed her career a year later and achieved some successes, most notably in Little Lord Fauntleroy (1936), and The Magnificent Ambersons (1942). She retired permanently from acting following her appearance in This is the Army (1943), again under the direction of Michael Curtiz.

In 1939, she married Dr. John Vruwink, an obstetrician who was her physician during her pregnancies, but they divorced in 1950. Costello spent the remaining years of her life in semi-seclusion, managing an avocado farm. Her film career was largely ruined by the destructive effects of early film makeup, which ravaged her complexion too severely to camouflage. Her final film was This Is the Army (1943). In the 1970s her house was inundated in a flash flood which destroyed a lot of her property and memorabilia from her movie career and life with John Barrymore.

Making a rare radio appearance, Costello appeared as the Danish Countess Elsa on the radio program Suspense with an air date of August 28, 1943. The title of the episode is The King's Birthday written by Corporal Leonard Pellitier US Army.

Shortly before her death, she was interviewed for the documentary series Hollywood (1980) discussing her film career. She died from emphysema in Fallbrook, California, in 1979, and is interred in Calvary Cemetery, East Los Angeles.