National Lampoon's Christmas Vacation originated from a short story by Writer John Hughes called "Christmas '59," which was published in the December 1980 issue of National Lampoon magazine. "The studio came to me and begged for another one, and I only agreed because I had a good story to base it on," said Hughes. "But those movies have become little more than Chevy Chase vehicles." Director Chris Columbus initially was to direct the film, but due to a personality clash between him and Chevy Chase, Columbus left the film and was replaced by Chechik. Hughes eventually gave Columbus the script to Home Alone..

Entertainment magazine Variety responded positively to the film stating, "Solid family fare with plenty of yocks, National Lampoon's Christmas Vacation is Chevy Chase and brood doing what they do best. Despite the title, which links it to previous pics in the rambling Vacation series, this third entry is firmly rooted at the Griswold family homestead, where Clark Griswold (Chase) is engaged in a typical over-reaching attempt to give his family a perfect, old-fashioned Christmas." Rita Kempley of The Washington Post gave the film a positive review explaining that "it will prove pater-familiar to fans of the 1983 original and the European Vacation sequel. Only it's a bit more whimsical."

Principal photography began on March 27, 1989 in Summit County, Colorado, with footage shot in Silverthorne, Breckenridge, and Frisco. From there the production moved to Warner Bros. Studio Facilities in Burbank, California, where the set of the Griswold family's house is located.

The film has achieved six home video releases: VHS and Laserdisc in early 1990, a bare bones DVD in 1997, and a "Special Edition" DVD in 2003. A Blu-ray edition was first released in 2006. In 2009, the film was released as an "Ultimate Collector's Edition." At the same time of this release, it was also released on a simple Blu-ray/DVD combo. A steelbook Blu-ray was released in 2015.

Despite several popular songs being present in the film, no official Soundtrack album was released. In 1999, a bootleg copy containing music featured in the film along with select cuts of dialogue dubbed as the "10th Anniversary Limited Edition" began to appear on Internet auction sites with the claim that Warner Bros. and RedDotNet had pressed 20,000 CDs for Six Flags Magic Mountain employees to sell to customers entering the park. However, while the discs were individually numbered out of 20,000, only 7,000 were sold as a part of an on demand production printed at gift shop kiosks within the park. Forums on movie music sites such as SoundtrackCollector later declared the disc to be a bootleg due to its inaccuracies. For instance, the cut "Christmas Vacation Medley" (claiming to be the work of Composer Angelo Badalamenti) is really a track called "Christmas at Carnegie Hall" from Home Alone 2: Lost in New York by Composer John Williams and does not actually contain any of Badalamenti's Christmas Vacation score.

The musical score for National Lampoon's Christmas Vacation was composed by Angelo Badalamenti. It is the only installment of the Vacation film series not to include Lindsey Buckingham's "Holiday Road". In its place is a song entitled "Christmas Vacation" that was written for the film by the husband-wife songwriting team of Barry Mann and Cynthia Weil and performed by Mavis Staples of The Staple Singers fame. The song was covered in 2007 by High School Musical star Monique Coleman for the 2007 Christmas album Disney Channel Holiday.