Galois was born on 25 October 1811 to Nicolas-Gabriel Galois and Adélaïde-Marie (born Demante). His father was a Republican and was head of Bourg-la-Reine's liberal party. His father became mayor of the village after Louis XVIII returned to the throne in 1814. His mother, the daughter of a jurist, was a fluent reader of Latin and classical literature and was responsible for her son's education for his first twelve years. At the age of 10, Galois was offered a place at the college of Reims, but his mother preferred to keep him at home.

In October 1823, he entered the Lycée Louis-le-Grand, and despite some turmoil in the school at the beginning of the term (when about a hundred students were expelled), Galois managed to perform well for the first two years, obtaining the first prize in Latin. He soon became bored with his studies and, at the age of 14, he began to take a serious interest in mathematics.

Galois lived during a time of political turmoil in France. Charles X had succeeded Louis XVIII in 1824, but in 1827 his party suffered a major electoral setback and by 1830 the opposition liberal party became the majority. Charles, faced with abdication, staged a coup d'état, and issued his notorious July Ordinances, touching off the July Revolution which ended with Louis-Philippe becoming king. While their counterparts at the Polytechnique were making history in the streets during les Trois Glorieuses, Galois and all the other students at the École Normale were locked in by the school's Director. Galois was incensed and wrote a blistering letter criticizing the Director, which he submitted to the Gazette des Écoles, signing the letter with his full name. Although the Gazette's Editor omitted the signature for publication, Galois was expelled.

In his first paper in 1828, Galois proved that the regular continued fraction which represents a quadratic surd ζ is purely periodic if and only if ζ is a reduced surd, that is, ${\displaystyle \zeta >1}$ and its conjugate ${\displaystyle \eta }$ satisfies ${\displaystyle -1<\eta <0}$.

Having been denied admission to the Polytechnique, Galois took the Baccalaureate examinations in order to enter the École Normale. He passed, receiving his degree on 29 December 1829. His examiner in mathematics reported, "This pupil is sometimes obscure in expressing his ideas, but he is intelligent and shows a remarkable spirit of research."

He submitted his memoir on equation theory several times, but it was never published in his lifetime due to various events. Though his first attempt was refused by Cauchy, in February 1830 following Cauchy's suggestion he submitted it to the Academy's secretary Joseph Fourier, to be considered for the Grand Prix of the Academy. Unfortunately, Fourier died soon after, and the memoir was lost. The prize would be awarded that year to Niels Henrik Abel posthumously and also to Carl Gustav Jacob Jacobi. Despite the lost memoir, Galois published three papers that year, one of which laid the foundations for Galois theory. The second one was about the numerical resolution of equations (root finding in modern terminology). The third was an important one in number theory, in which the concept of a finite field was first articulated.

Galois returned to mathematics after his expulsion from the École Normale, although he continued to spend time in political activities. After his expulsion became official in January 1831, he attempted to start a private class in advanced algebra which attracted some interest, but this waned, as it seemed that his political activism had priority. Siméon Poisson asked him to submit his work on the theory of equations, which he did on 17 January 1831. Around 4 July 1831, Poisson declared Galois' work "incomprehensible", declaring that "[Galois'] argument is neither sufficiently clear nor sufficiently developed to allow us to judge its rigor"; however, the rejection report ends on an encouraging note: "We would then suggest that the author should publish the whole of his work in order to form a definitive opinion." While Poisson's report was made before Galois' July 14 arrest, it took until October to reach Galois in prison. It is unsurprising, in the light of his character and situation at the time, that Galois reacted violently to the rejection letter, and decided to abandon publishing his papers through the Academy and instead publish them privately through his friend Auguste Chevalier. Apparently, however, Galois did not ignore Poisson's advice, as he began collecting all his mathematical manuscripts while still in prison, and continued polishing his ideas until his release on 29 April 1832, after which he was somehow talked into a duel.

From the closing lines of a letter from Galois to his friend Auguste Chevalier, dated May 29, 1832, two days before Galois' death:

Galois' mathematical contributions were published in full in 1843 when Liouville reviewed his manuscript and declared it sound. It was finally published in the October–November 1846 issue of the Journal de Mathématiques Pures et Appliquées. The most famous contribution of this manuscript was a novel proof that there is no quintic formula – that is, that fifth and higher degree equations are not generally solvable by radicals. Although Abel had already proved the impossibility of a "quintic formula" by radicals in 1824 and Ruffini had published a solution in 1799 that turned out to be flawed, Galois' methods led to deeper research in what is now called Galois theory. For Example, one can use it to determine, for any polynomial equation, whether it has a solution by radicals.

On 2 June, Évariste Galois was buried in a Common grave of the Montparnasse Cemetery whose exact location is unknown. In the cemetery of his native town – Bourg-la-Reine – a cenotaph in his honour was erected beside the graves of his relatives.