In The Big Blowdown, set a generation before Karras and Clay would appear (the 1950s), Pelecanos followed the lives of dozens of D.C. residents, tracking the challenges and changes that the second half of the twentieth century presented to Washingtonians. King Suckerman, set in the 1970s and generally regarded as the fans' favorite, introduced the recurring theme of basketball in Pelecanos' fiction. Typically, he employs the sport as a symbol of cooperation amongst the races, suggesting the dynamism of D.C. as reflective of the good will generated by multi-ethnic pick up games. However, he also indulges the reverse of the equation, wherein the basketball court becomes the site of unresolved hostilities. In such cases, violent Criminal behavior typically emerges amongst the participants, usually escalating the mystery. The Sweet Forever (1980s) and Shame the Devil (1990s) closed the quartet and Pelecanos retired Stefanos and the other characters that populated the novels. (Stefanos and other characters do re-appear in subsequent works.)

Pelecanos, a Greek American, was born in Washington, D.C. in 1957.

In 2001, he introduced a new team of private detectives, Derek Strange and Terry Quinn, as the protagonists of Right as Rain. They have subsequently starred in the author's more recent works Hell to Pay (which won a Gumshoe Award in 2003) and Soul Circus. While these books have cemented the author's reputation as one of the best current American crime Writers and sold consistently, they have not garnered the critical and cult affection his D.C. quartet did. Rather, they seem to be continuing the author's well received formula of witty protagonists chasing unconflicted Criminals behind the backdrop of popular culture references and D.C. landmarks.

Pelecanos joined the crew as a Writer for the first season in 2002. He wrote the teleplay for the season's penultimate episode, "Cleaning Up", from a story by Simon and Ed Burns. Pelecanos was promoted to Producer for the second season in 2003. He wrote the teleplay for the episodes "Duck and Cover" and "Bad Dreams" from stories he co-wrote with Simon. He remained a Writer and Producer for the third season in 2004. He wrote the teleplay for the episodes "Hamsterdam" and "Middle Ground" from stories he co-wrote with Simon. Simon wrote the teleplay for the episode "Slapstick" from a story he co-wrote with Pelecanos. Simon and Pelecanos' collaboration on "Middle Ground" received the show's first Emmy Award nomination, in the category Outstanding Writing for a Drama Series. Pelecanos left the production staff of The Wire after the show's third season to concentrate on writing his novel The Night Gardener. His role as a Producer was taken on by Eric Overmyer.

Perhaps sensing this, Pelecanos again switched his focus in his 2004 novel, Hard Revolution, taking one of his new detectives, Derek Strange, back in time to his early days on the D.C. police force. In another interesting move, Pelecanos attached a CD to the book itself, emulating Michael Connelly who included a CD with his 2003 Harry Bosch book Lost Light.

In 2005, Pelecanos saw another novel published, Drama City. This book revisited the examination of dogfighting begun in his book Hell To Pay. Pelecanos is a dog owner and has written about his views of dogfighting.

As of 2006, Pelecanos lives in the Washington, D.C. suburb of Silver Spring, Maryland with his wife and three children.

The Turnaround was published in August 2008, reflecting a return to his roots, as the novel opens in the 70s in a Greek diner, and a continuation of his more modern style in the portion set in the present. The Turnaround won the 2008's Hammett Prize.

Also in 2010 Pelecanos joined the crew of HBO New Orleans drama Treme as a Writer. The series was created by Simon and Overmeyer. It follows the lives of residents of the Tremé neighborhood after Hurricane Katrina. Pelecanos wrote the teleplay for the episode "At the Foot of Canal Street" from a story he co-wrote with Overmyer. Pelecanos returned as a Consulting Producer and Writer for the second season in 2011. He joined the crew full-time as a Writer and executive Producer for the third season in 2012. He remained in this role for the fourth and final season in 2013.

In 2011, Pelecanos published The Cut, introducing the character Spero Lucas, a young veteran of the Iraq war. The former Marine works part-time as a private investigator for a D.C. defense attorney as well as taking jobs finding stolen items for a 40% cut of the value of the returned item. In 2013, Pelecanos published The Double, the second Spero Lucas book.

In 2017, HBO Premiered The Deuce, a new series developed by Pelecanos and David Simon. The show focuses on the birth of the pornography industry in 1970s Times Square. George also co-authored several of the teleplays, including the Pilot with Simon, and co-authored episodes with Richard Price and Lisa Lutz.