Guo was born in Shen County, Shandong province, People's Republic of China. He is the seventh of eight children in the family. He began his Business career in Zhengzhou, before moving to Beijing to secure various construction deals during the 2008 Beijing Olympics. His most famous asset was the Pangu Plaza, an Olympic torch-shaped condominium residence built prior to the Beijing games.

Beijing Zenith Holdings was a company that owned by Li Lin and Jiang Yuehua (in 2013) via two corporate entities (Chinese: 郑州浩云实业有限公司 and 郑州浩天实业有限公司). The company acquired a minority stake in PKU Health care from state-owned Founder Group's PKU Health care Group. However, Beijing Zenith Holdings allegedly failed to pay the PKU Health care Group after the shares were already transferred, thus Beijing Zenith Holdings allegedly borrowed the money from PKU Resources Group Holdings, sister company of PKU Health care Group to allegedly finalize the payment. All three companies were fined by China Securities Regulatory Commission in 2016.

In 2015, Caixin media head Hu Shuli published a lengthy investigative piece on Guo and his associates. Guo responded by claiming Hu defamed him and responded with a set of personal accusations against Hu. Guo was believed to have left China sometime in 2015; since then he is believed to have been shuttling between Europe and the United States. He opened a Twitter account in early 2017, frequently criticizing individuals within the Chinese establishment. He has reserved particular scorn for He Jintao (not to be confused with former general secretary Hu Jintao), the son of former Central Commission for Discipline Inspection secretary He Guoqiang.

In June 2017, staff of one of Guo's other investment vehicles, Pangu Investment, were charged for scamming banks on loans. The staff members accused all alleged that they were under the orders of Guo.