Isaac Newton was born (according to the Julian calendar, in use in England at the time) on Christmas Day, 25 December 1642 (NS 4 January 1643) "an hour or two after midnight", at Woolsthorpe Manor in Woolsthorpe-by-Colsterworth, a hamlet in the county of Lincolnshire. His father, also named Isaac Newton, had died three months before. Born prematurely, Newton was a small child; his mother Hannah Ayscough reportedly said that he could have fit inside a quart mug. When Newton was three, his mother remarried and went to live with her new husband, the Reverend Barnabas Smith, leaving her son in the care of his maternal grandmother, Margery Ayscough. The young Isaac disliked his stepfather and maintained some enmity towards his mother for marrying him, as revealed by this entry in a list of sins committed up to the age of 19: "Threatening my father and mother Smith to burn them and the house over them." Newton's mother had three children from her second marriage.

From the age of about twelve until he was seventeen, Newton was educated at The King's School, Grantham, which taught Latin and Greek and probably imparted a significant foundation of mathematics. He was removed from school, and by October 1659, he was to be found at Woolsthorpe-by-Colsterworth, where his mother, widowed for a second time, attempted to make a farmer of him. Newton hated farming. Henry Stokes, master at the King's School, persuaded his mother to send him back to school so that he might complete his education. Motivated partly by a Desire for revenge against a schoolyard bully, he became the top-ranked student, distinguishing himself mainly by building sundials and Models of windmills.

It is known from his notebooks that Newton was grappling in the late 1660s with the idea that terrestrial gravity extends, in an inverse-square proportion, to the Moon; however it took him two decades to develop the full-fledged theory. The question was not whether gravity existed, but whether it extended so far from Earth that it could also be the force holding the Moon to its orbit. Newton showed that if the force decreased as the inverse square of the distance, one could indeed calculate the Moon's orbital period, and get good agreement. He guessed the same force was responsible for other orbital motions, and hence named it "universal gravitation".

In June 1661, he was admitted to Trinity College, Cambridge, on the recommendation of his uncle Rev william Ayscough, who had studied there. He started as a subsizar—paying his way by performing valet's duties—until he was awarded a scholarship in 1664, guaranteeing him four more years until he could get his MA. At that time, the college's teachings were based on those of Aristotle, whom Newton supplemented with modern Philosophers such as Descartes, and astronomers such as Galileo and Thomas Street, through whom he learned of Kepler's work. He set down in his notebook a series of "Quaestiones" about mechanical philosophy as he found it. In 1665, he discovered the generalised binomial theorem and began to develop a mathematical theory that later became calculus. Soon after Newton had obtained his BA degree in August 1665, the university temporarily closed as a precaution against the Great Plague. Although he had been undistinguished as a Cambridge student, Newton's private studies at his home in Woolsthorpe over the subsequent two years saw the development of his theories on calculus, optics, and the law of gravitation.

In 1666, Newton observed that the spectrum of colours exiting a prism in the position of minimum deviation is oblong, even when the light ray entering the prism is circular, which is to say, the prism refracts different colours by different angles. This led him to conclude that colour is a property intrinsic to light—a point which had been debated in prior years.

When Newton received his MA and became a Fellow of the "College of the Holy and Undivided Trinity" in 1667, he made the commitment that "I will either set Theology as the object of my studies and will take holy orders when the time prescribed by these statutes [7 years] arrives, or I will resign from the college." Up till this point he had not thought much about religion and had twice signed his agreement to the thirty-nine articles, the basis of Church of England doctrine.

From this work, he concluded that the lens of any refracting telescope would suffer from the dispersion of light into colours (chromatic aberration). As a proof of the concept, he constructed a telescope using reflective mirrors instead of lenses as the objective to bypass that Problem. Building the design, the first known functional reflecting telescope, today known as a Newtonian telescope, involved solving the Problem of a suitable mirror material and shaping technique. Newton ground his own mirrors out of a custom composition of highly reflective speculum metal, using Newton's rings to judge the quality of the optics for his telescopes. In late 1668 he was able to produce this first reflecting telescope. It was about eight inches long and it gave a clearer and larger image. In 1671, the Royal Society asked for a demonstration of his reflecting telescope. Their interest encouraged him to publish his notes, Of Colours, which he later expanded into the work Opticks. When Robert Hooke criticised some of Newton's ideas, Newton was so offended that he withdrew from public debate. Newton and Hooke had brief exchanges in 1679–80, when Hooke, appointed to manage the Royal Society's correspondence, opened up a correspondence intended to elicit contributions from Newton to Royal Society transactions, which had the effect of stimulating Newton to work out a proof that the elliptical form of planetary orbits would result from a centripetal force inversely proportional to the square of the radius vector (see Newton's law of universal gravitation – History and De motu corporum in gyrum). But the two men remained generally on poor terms until Hooke's death.

He was appointed Lucasian Professor of Mathematics in 1669 on Barrow's recommendation. During that time, any Fellow of a college at Cambridge or Oxford was required to take holy orders and become an ordained Anglican priest. However, the terms of the Lucasian professorship required that the holder not be active in the church (presumably so as to have more time for science). Newton argued that this should exempt him from the ordination requirement, and Charles II, whose permission was needed, accepted this argument. Thus a conflict between Newton's religious views and Anglican orthodoxy was averted.

From 1670 to 1672, Newton lectured on optics. During this period he investigated the refraction of light, demonstrating that the multicoloured spectrum produced by a prism could be recomposed into white light by a lens and a second prism. Modern scholarship has revealed that Newton's analysis and resynthesis of white light owes a debt to corpuscular alchemy.

By 1672 he had started to record his theological researches in notebooks which he showed to no one and which have only recently been examined. They demonstrate an extensive knowledge of early church writings and show that in the conflict between Athanasius and Arius which defined the Creed, he took the side of Arius, the loser, who rejected the conventional view of the Trinity. Newton "recognized Christ as a Divine mediator between God and man, who was subordinate to the Father who created him." He was especially interested in prophecy, but for him, "the great apostasy was trinitarianism."

Newton tried unsuccessfully to obtain one of the two fellowships that exempted the holder from the ordination requirement. At the last moment in 1675 he received a dispensation from the government that excused him and all Future holders of the Lucasian chair.

Newton was relatively modest about his achievements, writing in a letter to Robert Hooke in February 1676:

In 1679, Newton returned to his work on (celestial) mechanics by considering gravitation and its effect on the orbits of planets with reference to Kepler's laws of planetary motion. This followed stimulation by a brief exchange of letters in 1679–80 with Hooke, who had been appointed to manage the Royal Society's correspondence, and who opened a correspondence intended to elicit contributions from Newton to Royal Society transactions. Newton's reawakening interest in astronomical matters received further stimulus by the appearance of a comet in the winter of 1680–1681, on which he corresponded with John Flamsteed. After the exchanges with Hooke, Newton worked out proof that the elliptical form of planetary orbits would result from a centripetal force inversely proportional to the square of the radius vector (see Newton's law of universal gravitation – History and De motu corporum in gyrum). Newton communicated his results to Edmond Halley and to the Royal Society in De motu corporum in gyrum, a tract written on about nine sheets which was copied into the Royal Society's Register Book in December 1684. This tract contained the nucleus that Newton developed and expanded to form the Principia.

Because of this, the Principia has been called "a book dense with the theory and application of the infinitesimal calculus" in modern times and "lequel est presque tout de ce calcul" ('nearly all of it is of this calculus') in Newton's time. His use of methods involving "one or more orders of the infinitesimally small" is present in his De motu corporum in gyrum of 1684 and in his papers on motion "during the two decades preceding 1684".

The Principia was published on 5 July 1687 with encouragement and financial help from Edmond Halley. In this work, Newton stated the three universal laws of motion. Together, these laws describe the relationship between any object, the forces acting upon it and the resulting motion, laying the foundation for classical mechanics. They contributed to many advances during the Industrial Revolution which soon followed and were not improved upon for more than 200 years. Many of these advancements continue to be the underpinnings of non-relativistic technologies in the modern world. He used the Latin word gravitas (weight) for the effect that would become known as gravity, and defined the law of universal gravitation.

Newton did have a close friendship with the Swiss Mathematician Nicolas Fatio de Duillier, whom he met in London around 1689. Their intense relationship came to an abrupt and unexplained end in 1693, and at the same time Newton suffered a nervous breakdown. Some of their correspondence has survived.

In the 1690s, Newton wrote a number of religious tracts dealing with the literal and symbolic interpretation of the Bible. A manuscript Newton sent to John Locke in which he disputed the fidelity of 1 John 5:7 and its fidelity to the original manuscripts of the New Testament, remained unpublished until 1785.

Newton had been reluctant to publish his calculus because he feared controversy and criticism. He was close to the Swiss Mathematician Nicolas Fatio de Duillier. In 1691, Duillier started to write a new version of Newton's Principia, and corresponded with Leibniz. In 1693, the relationship between Duillier and Newton deteriorated and the book was never completed.

As Warden, and afterwards Master, of the Royal Mint, Newton estimated that 20 percent of the coins taken in during the Great Recoinage of 1696 were counterfeit. Counterfeiting was high treason, punishable by the felon being hanged, drawn and quartered. Despite this, convicting even the most flagrant Criminals could be extremely difficult. However, Newton proved equal to the task.

Starting in 1699, other members of the Royal Society (of which Newton was a member) accused Leibniz of plagiarism. The dispute then broke out in full force in 1711 when the Royal Society proclaimed in a study that it was Newton who was the true discoverer and labelled Leibniz a fraud. This study was cast into doubt when it was later found that Newton himself wrote the study's concluding remarks on Leibniz. Thus began the bitter controversy which marred the lives of both Newton and Leibniz until the latter's death in 1716.

Newton was made President of the Royal Society in 1703 and an associate of the French Académie des Sciences. In his position at the Royal Society, Newton made an enemy of John Flamsteed, the Astronomer Royal, by prematurely publishing Flamsteed's Historia Coelestis Britannica, which Newton had used in his studies.

In a manuscript he wrote in 1704 (never intended to be published) he mentions the date of 2060, but it is not given as a date for the end of days. It has been falsely reported as a prediction. The passage is clear, when the date is read in context. He was against date setting for the end of days, concerned that this would put Christianity into disrepute.

In April 1705, Queen Anne knighted Newton during a royal visit to Trinity College, Cambridge. The knighthood is likely to have been motivated by political considerations connected with the Parliamentary election in May 1705, rather than any recognition of Newton's scientific work or services as Master of the Mint. Newton was the second scientist to be knighted, after Sir Francis Bacon.

Newton's postulate of an invisible force able to act over vast distances led to him being criticised for introducing "occult agencies" into science. Later, in the second edition of the Principia (1713), Newton firmly rejected such criticisms in a concluding General Scholium, writing that it was enough that the phenomena implied a gravitational attraction, as they did; but they did not so far indicate its cause, and it was both unnecessary and improper to frame hypotheses of things that were not implied by the phenomena. (Here Newton used what became his famous expression "hypotheses non-fingo").

As a result of a report written by Newton on 21 September 1717 to the Lords Commissioners of His Majesty's Treasury the bimetallic relationship between gold coins and silver coins was changed by Royal proclamation on 22 December 1717, forbidding the exchange of gold guineas for more than 21 silver shillings. This inadvertently resulted in a silver shortage as silver coins were used to pay for imports, while exports were paid for in gold, effectively moving Britain from the silver standard to its first gold standard. It is a matter of debate as whether he intended to do this or not. It has been argued that Newton conceived of his work at the Mint as a continuation of his alchemical work.

Newton himself often told the story that he was inspired to formulate his theory of gravitation by watching the fall of an apple from a tree. Although it has been said that the apple story is a myth and that he did not arrive at his theory of gravity in any single moment, acquaintances of Newton (such as william Stukeley, whose manuscript account of 1752 has been made available by the Royal Society) do in fact confirm the incident, though not the cartoon version that the apple actually hit Newton's head. Stukeley recorded in his Memoirs of Sir Isaac Newton's Life a conversation with Newton in Kensington on 15 April 1726:

In similar terms, Voltaire wrote in his Essay on Epic Poetry (1727), "Sir Isaac Newton walking in his gardens, had the first thought of his system of gravitation, upon seeing an apple falling from a tree."

Newton's monument (1731) can be seen in Westminster Abbey, at the north of the entrance to the choir against the choir screen, near his tomb. It was executed by the Sculptor Michael Rysbrack (1694–1770) in white and grey marble with design by the Architect william Kent. The monument features a figure of Newton reclining on top of a sarcophagus, his right elbow resting on several of his great books and his left hand pointing to a scroll with a mathematical design. Above him is a pyramid and a celestial globe showing the signs of the Zodiac and the path of the comet of 1680. A relief panel depicts putti using instruments such as a telescope and prism. The Latin inscription on the base translates as:

In 1816, a tooth said to have belonged to Newton was sold for £730 (us$3,633) in London to an aristocrat who had it set in a ring. The Guinness World Records 2002 Classified it as the most valuable tooth, which would value approximately £25,000 (us$35,700) in late 2001. Who bought it and who currently has it has not been disclosed.

In 1888, after spending sixteen years cataloging Newton's papers, Cambridge University kept a small number and returned the rest to the Earl of Portsmouth. In 1936, a descendant offered the papers for sale at Sotheby's. The collection was broken up and sold for a total of about £9,000. John Maynard Keynes was one of about three dozen bidders who obtained part of the collection at auction. Keynes went on to reassemble an estimated half of Newton's collection of papers on alchemy before donating his collection to Cambridge University in 1946.

In the character of Morton Opperly in "Poor Superman" (1951), speculative fiction author Fritz Leiber says of Newton, "Everyone knows Newton as the great scientist. Few remember that he spent half his life muddling with alchemy, looking for the philosopher's stone. That was the pebble by the seashore he really wanted to find."

From 1978 until 1988, an image of Newton designed by Harry Ecclestone appeared on Series D £1 banknotes issued by the Bank of England (the last £1 notes to be issued by the Bank of England). Newton was shown on the reverse of the notes holding a book and accompanied by a telescope, a prism and a map of the Solar System.

A statue of Isaac Newton, looking at an apple at his feet, can be seen at the Oxford University Museum of Natural History. A large bronze statue, Newton, after william Blake, by Eduardo Paolozzi, dated 1995 and inspired by Blake's etching, dominates the piazza of the British Library in London.

Albert Einstein kept a picture of Newton on his study wall alongside ones of Michael Faraday and James Clerk Maxwell. Newton remains influential to today's Scientists, as demonstrated by a 2005 survey of members of Britain's Royal Society (formerly headed by Newton) asking who had the greater effect on the history of science, Newton or Einstein. Royal Society Scientists deemed Newton to have made the greater overall contribution. In 1999, an opinion poll of 100 of today's leading physicists voted Einstein the "greatest Physicist ever;" with Newton the runner-up, while a parallel survey of rank-and-file physicists by the site PhysicsWeb gave the top spot to Newton.

Enlightenment Philosophers chose a short history of scientific predecessors – Galileo, Boyle, and Newton principally – as the guides and guarantors of their applications of the singular concept of nature and natural law to every physical and social field of the day. In this respect, the lessons of history and the social structures built upon it could be discarded.

In Newton's eyes, worshipping Christ as God was idolatry, to him the fundamental sin. Historian Stephen D. Snobelen says, "Isaac Newton was a heretic. But ... he never made a public declaration of his private faith—which the orthodox would have deemed extremely radical. He hid his faith so well that scholars are still unravelling his personal beliefs." Snobelen concludes that Newton was at least a Socinian sympathiser (he owned and had thoroughly read at least eight Socinian books), possibly an Arian and almost certainly an anti-trinitarian.