She has been married to Dr. Lorenzo Brown, a former Economist, since 1970. The family made Stockholm, Sweden their home for nine years while the couple had two sons, Randy and Russell, and Foster attended university. Her son Randy was wounded by gunfire in 1992 when he was 17 years old, and Foster appeared on NBC's America the Violent with Tom Brokaw to discuss the issue of violence from a parent's perspective. Her husband and two sons now work for the magazine.

In 1979, Brown started a ticket company, Washington Theater Group. She then worked for Robert Johnson's Black Entertainment Television (BET), first in advertising as a secretary and then later was promoted to a TV Producer for Video Soul and Video LP programs until leaving in 1987. As a TV Producer, Brown had met musical talent, such as Whitney Houston and others, and would later use her contacts for her entertainment reporting. Brown has said in interviews that she is not a Writer but an interviewer and storyteller, and she wanted to write stories about how celebrities were made. Brown formed the idea for her own magazine while writing for Impact magazine and other publications.

Jamie Foster Brown has owned and published Sister 2 Sister magazine since its launch in 1988. Her magazine was published from Lanham, Maryland and later from Takoma Park, Maryland. Expanding on the brand, Brown created and serves as an entertainment Journalist for the syndicated radio program Sister 2 Sister Celebrity Update While at Sister 2 Sister, Brown was a regular guest on the Joan Rivers Show and on the Tom Joyner Morning Show.

In 2008, a judge ordered rap Artist DMX to pay 1.5 million to Monique Wayne because of a comment he had made to Jamie Foster Brown in a 2006 interview for Sister 2 Sister magazine alleging that a woman had raped him and given birth to his child. Her original suit was for "defamation, false statements and 'unreasonable publicity' about her private life".

Jamie Foster Brown's hometown is Chicago, Illinois. Brown and her sister Stella Foster were raised in an Englewood, Chicago neighborhood. Her parents were Peter James and Mamie Lee Foster and they were neighborhood storekeepers. She was educated at Calumet High School, started college in Chicago, and later transferred and then graduated with a B.A. from Stockholm University. Her sister Stella Foster also wrote for Sister 2 Sister magazine, worked with Irv Kupcinet, an entertainment Journalist at the Chicago Sun-Times, and after his death wrote her own column and retired in 2012.

Jamie Foster Brown appeared on the cover of the November 2013 issue of Sister 2 Sister magazine as it celebrated its 25th anniversary, and was interviewed.