Cooper had a recurring role as Valerie Harris on four episodes of the Fox TV series 24, portraying a Homeland Security official who was part of a takeover of the Counter Terrorism Unit. She said in a Toronto Star interview in 2008 that the project reunited her with Jon Cassar, the show's executive Producer who had directed her on Jake and the Kid. Because each season of the show took place on one day, she never had a wardrobe change. She said, "You get six or seven multiples of the same outfit. Good thing I look good in blue. I had a navy blue suit with a light blue shirt."

In 2013, Cooper was the Screenwriter, co-producer and one of the lead actors on the Canadian film I Think I Do. The romantic comedy was set in Edmonton and also filmed on location in the city. Cooper portrayed the sister of characters portrayed by Mia Kirshner and Sara Canning, who together run a wedding planning company.

Cooper is a regular cast member of the 2015 Open Heart TV series, a mystery drama commissioned by the YTV and TeenNick channels that is being created by the producers of the Degrassi TV shows. She portrays Jane Blake, the leading trauma surgeon at Open Heart Memorial who would rather save lives than tend to her own family affairs. Her daughter Dylan, portrayed by Karis Cameron, takes a job as hospital volunteer and secretly attempts to solve the disappearance of her father.