Rizzo started her career as singer, performing together with her husband Marco Toto as Guitarist. In 1989, the couple, who had already starred in some amateur videos with their faces covered by masks, accepted to star in a pornographic film, Giochi bestiali in famiglia. That film, once it was theatrically released, created a stir in their hometown and drew the attention of the press and of the Italian television, launching her career. She then appeared in numerous other pornographic films (even working with Gerard Damiano), and she founded the company Jessica Rizzo Communications, which produces amateur videos and which she works for both as a Director and performer.

Thanks to her success, Rizzo even works as stage Actress, and she made her theatrical debut in 1995, in Il nulla by Dario D'Ambrosi. In 2003, she was directed by Arnolfo Petri in Albert Camus' Caligula. She also launched her own line of lingerie and perfume. In 2011, Rizzo and her husband were involved in a case of tax evasion, for evading about 16 million Euros.