Goethe's father, Johann Caspar Goethe, lived with his family in a large house in Frankfurt, then an Imperial Free City of the Holy Roman Empire. Though he had studied law in Leipzig and had been appointed Imperial Councillor, he was not involved in the city's official affairs. Johann Caspar married Goethe's mother, Catharina Elizabeth Textor at Frankfurt on 20 August 1748, when he was 38 and she was 17. All their children, with the exception of Johann Wolfgang and his sister, Cornelia Friederica Christiana, who was born in 1750, died at early ages.

The first production of Richard Wagner's opera Lohengrin took place in Weimar in 1850. The Conductor was Franz Liszt, who chose the date 28 August in honour of Goethe, who was born on 28 August 1749.

Goethe became also acquainted with Frankfurt actors. Among early literary attempts, he was infatuated with Gretchen, who would later reappear in his Faust and the adventures with whom he would concisely describe in Dichtung und Wahrheit. He adored Caritas Meixner (27 July 1750 – 31 December 1773), a wealthy Worms trader's daughter and friend of his sister, who would later marry the merchant G. F. Schuler.

Born into a Lutheran family, Goethe's early faith was shaken by news of such events as the 1755 Lisbon earthquake and the Seven Years' War. His later spiritual perspective incorporated elements of pantheism (heavily influenced by Spinoza), humanism, and various elements of Western esotericism, as seen most vividly in Part II of Faust. A year before his death, in a letter to Sulpiz Boisserée, Goethe wrote that he had the feeling that all his life he had been aspiring to qualify as one of the Hypsistarians, an ancient Jewish-pagan sect of the Black Sea region who, in his understanding, sought to reverence, as being close to the Godhead, what came to their knowledge of the best and most perfect. He also had an affinity for Jews, writing "Energy is the basis of everything. Every Jew, no matter how insignificant, is engaged in some decisive and immediate pursuit of a goal. They are the most perpetual people of the earth."

Goethe studied law at Leipzig University from 1765 to 1768. He detested learning age-old judicial rules by heart, preferring instead to attend the poetry lessons of Christian Fürchtegott Gellert. In Leipzig, Goethe fell in love with Anna Katharina Schönkopf and wrote cheerful verses about her in the Rococo genre. In 1770, he anonymously released Annette, his first collection of poems. His uncritical admiration for many contemporary poets vanished as he became interested in Gotthold Ephraim Lessing and Christoph Martin Wieland. Already at this time, Goethe wrote a good deal, but he threw away nearly all of these works, except for the comedy Die Mitschuldigen. The restaurant Auerbachs Keller and its legend of Faust's 1525 barrel ride impressed him so much that Auerbachs Keller became the only real place in his closet drama Faust Part One. As his studies did not progress, Goethe was forced to return to Frankfurt at the close of August 1768.

On a trip to the village Sessenheim, Goethe fell in love with Friederike Brion, in October 1770, but, after ten months, terminated the relationship in August 1771. Several of his poems, like "Willkommen und Abschied", "Sesenheimer Lieder" and "Heidenröslein", originate from this time.

At the end of August 1771, Goethe acquired the academic degree of the Lizenziat (Licentia docendi) in Frankfurt and established a small legal practice. Although in his academic work he had expressed the ambition to make jurisprudence progressively more humane, his inexperience led him to proceed too vigorously in his first cases, and he was reprimanded and lost further ones. This prematurely terminated his career as a Lawyer after only a few months. At this time, Goethe was acquainted with the court of Darmstadt, where his inventiveness was praised. From this milieu came Johann Georg Schlosser (who was later to become his brother-in-law) and Johann Heinrich Merck. Goethe also pursued literary plans again; this time, his father did not have anything against it, and even helped. Goethe obtained a copy of the biography of a noble highwayman from the German Peasants' War. In a couple of weeks the biography was reworked into a colourful drama. Entitled Götz von Berlichingen, the work went directly to the heart of Goethe's contemporaries.

Goethe outlines his method in the essay The experiment as mediator between subject and object (1772). In the Kurschner edition of Goethe's works, the science Editor, Rudolf Steiner, presents Goethe's approach to science as phenomenological. Steiner elaborated on that in the books The Theory of Knowledge Implicit in Goethe's World-Conception and Goethe's World View, in which he characterizes intuition as the instrument by which one grasps Goethe's biological archetype—The Typus.

The most important of Goethe's works produced before he went to Weimar were Götz von Berlichingen (1773), a tragedy that was the first work to bring him recognition, and the novel The Sorrows of Young Werther (German: Die Leiden des jungen Werthers) (1774), which gained him enormous fame as a Writer in the Sturm und Drang period which marked the early phase of Romanticism. Indeed, Werther is often considered to be the "spark" which ignited the movement, and can arguably be called the world's first "best-seller." During the years at Weimar before he met Schiller he began Wilhelm Meister's Apprenticeship, wrote the dramas Iphigenie auf Tauris (Iphigenia in Tauris), Egmont, Torquato Tasso, and the fable Reineke Fuchs.

The short epistolary novel, Die Leiden des jungen Werthers, or The Sorrows of Young Werther, published in 1774, recounts an unhappy romantic infatuation that ends in suicide. Goethe admitted that he "shot his hero to save himself": a reference to Goethe's own near-suicidal obsession with a young woman during this period, an obsession he quelled through the writing process. The novel remains in print in dozens of languages and its influence is undeniable; its central hero, an obsessive figure driven to despair and destruction by his unrequited love for the young Lotte, has become a pervasive literary archetype. The fact that Werther ends with the protagonist's suicide and funeral—a funeral which "no clergyman attended"—made the book deeply controversial upon its (anonymous) publication, for on the face of it, it appeared to condone and glorify suicide. Suicide is considered sinful by Christian doctrine: suicides were denied Christian burial with the bodies often mistreated and dishonoured in various ways; in corollary, the deceased's property and possessions were often confiscated by the Church. However, Goethe explained his use of Werther in his autobiography. He said he "turned reality into poetry but his friends thought poetry should be turned into reality and the poem imitated." He was against this reading of poetry. Epistolary novels were Common during this time, letter-writing being a primary mode of communication. What set Goethe's book apart from other such novels was its expression of unbridled longing for a joy beyond possibility, its sense of defiant rebellion against authority, and of principal importance, its total subjectivity: qualities that trailblazed the Romantic movement.

In 1775, Goethe was invited, on the strength of his fame as the author of The Sorrows of Young Werther, to the court of Karl August, Duke of Saxe-Weimar-Eisenach, who would become Grand Duke in 1815. (The Duke at the time was 18 years of age, to Goethe's 26.) Goethe thus went to live in Weimar, where he remained for the rest of his life and where, over the course of many years, he held a succession of offices, becoming the Duke's friend and chief adviser.

In 1776, Goethe formed a close relationship to Charlotte von Stein, an older, married woman. The intimate bond with von Stein lasted for ten years, after which Goethe abruptly left for Italy without giving his companion any notice. She was emotionally distraught at the time, but they were eventually reconciled.

Goethe, aside from official duties, was also a friend and confidant to the Duke, and participated fully in the activities of the court. For Goethe, his first ten years at Weimar could well be described as a garnering of a degree and range of experience which perhaps could be achieved in no other way. In 1779, Goethe took on the War Commission of the Grand Duchy of Saxe-Weimar, in addition to the Mines and Highways commissions. In 1782, when the chancellor of the Duchy's Exchequer left his office, Goethe agreed to act in his place for two and a half years; this post virtually made him prime minister and the principal representative of the Duchy. Goethe was ennobled in 1782 (this being indicated by the "von" in his name).

A literary Celebrity by the age of 25, Goethe was ennobled by the Duke of Saxe-Weimar, Carl August in 1782 after taking up residence there in November 1775 following the success of his first novel, The Sorrows of Young Werther (1774). He was an early participant in the Sturm und Drang literary movement. During his first ten years in Weimar, Goethe was a member of the Duke's privy council, sat on the war and highway commissions, oversaw the reopening of silver mines in nearby Ilmenau, and implemented a series of administrative reforms at the University of Jena. He also contributed to the planning of Weimar's botanical park and the rebuilding of its Ducal Palace, which in 1998 were together designated a UNESCO World Heritage Site under the name Classical Weimar.

His focus on morphology and what was later called homology influenced 19th century Naturalists, although his ideas of transformation were about the continuous metamorphosis of living things and did not relate to contemporary ideas of "transformisme" or transmutation of species. Homology, or as Étienne Geoffroy Saint-Hilaire called it "analogie", was used by Charles Darwin as strong evidence of Common descent and of laws of variation. Goethe's studies (notably with an elephant's skull lent to him by Samuel Thomas von Soemmerring) led him to independently discover the human intermaxillary bone, also known as "Goethe's bone", in 1784, which Broussonet (1779) and Vicq d'Azyr (1780) had (using different methods) identified several years earlier. While not the only one in his time to question the prevailing view that this bone did not exist in humans, Goethe, who believed ancient anatomists had known about this bone, was the first to prove its existence in all mammals. The elephant's skull that led Goethe to this discovery, and was subsequently named the Goethe Elephant, still exists and is displayed in the Ottoneum in Kassel, Germany.

Goethe's journey to the Italian peninsula and Sicily from 1786 to 1788 was of great significance in his aesthetic and philosophical development. His father had made a similar journey during his own youth, and his Example was a major motivating factor for Goethe to make the trip. More importantly, however, the work of Johann Joachim Winckelmann had provoked a general renewed interest in the classical art of ancient Greece and Rome. Thus Goethe's journey had something of the nature of a pilgrimage to it. During the course of his trip Goethe met and befriended the artists Angelica Kauffman and Johann Heinrich Wilhelm Tischbein, as well as encountering such notable characters as Lady Hamilton and Alessandro Cagliostro (see Affair of the Diamond Necklace).

Goethe's first major scientific work, the Metamorphosis of Plants, was published after he returned from a 1788 tour of Italy. In 1791, he was made managing Director of the theatre at Weimar, and in 1794 he began a friendship with the dramatist, Historian, and Philosopher Friedrich Schiller, whose plays he premiered until Schiller's death in 1805. During this period, Goethe published his second novel, Wilhelm Meister's Apprenticeship; the verse epic Hermann and Dorothea, and, in 1808, the first part of his most celebrated drama, Faust. His conversations and various Common undertakings throughout the 1790s with Schiller, Johann Gottlieb Fichte, Johann Gottfried Herder, Alexander von Humboldt, Wilhelm von Humboldt, and August and Friedrich Schlegel have come to be collectively termed Weimar Classicism.

In late 1792, Goethe took part in the battle of Valmy against revolutionary France, assisting Duke Carl August of Saxe-Weimar during the failed invasion of France. Again during the Siege of Mainz he assisted Carl August as a military observer. His written account of these events can be found within his Complete Works.

In 1794, Friedrich Schiller wrote to Goethe offering friendship; they had previously had only a mutually wary relationship ever since first becoming acquainted in 1788. This collaborative friendship lasted until Schiller's death in 1805.

Thinkers such as Ralph Waldo Emerson would take up many similar ideas in the 1800s. Goethe's ideas on evolution would frame the question that Darwin and Wallace would approach within the scientific paradigm. The Serbian Inventor and electrical Engineer Nikola Tesla was heavily influenced by Goethe's Faust, his favorite poem, and had actually memorized the entire text. It was while reciting a certain verse that he was struck with the epiphany that would lead to the idea of the rotating magnetic field and ultimately, alternating current.

To the period of his friendship with Schiller belong the conception of Wilhelm Meister's Journeyman Years (the continuation of Wilhelm Meister's Apprenticeship), the idyll of Hermann and Dorothea, the Roman Elegies and the verse drama The Natural Daughter. In the last period, between Schiller's death, in 1805, and his own, appeared Faust Part One, Elective Affinities, the West-Eastern Diwan (a collection of poems in the Persian style, influenced by the work of Hafez), his autobiographical Aus meinem Leben: Dichtung und Wahrheit (From My Life: Poetry and Truth) which covers his early life and ends with his departure for Weimar, his Italian Journey, and a series of treatises on art. His writings were immediately influential in literary and artistic circles.

Days afterward, on 19 October 1806, Goethe legitimized their 18-year relationship by marrying Christiane in a quiet marriage Service at the Jakobskirche in Weimar (de). They had already had several children together by this time, including their son, Julius August Walter von Goethe (25 December 1789 – 28 October 1830), whose wife, Ottilie von Pogwisch (de) (31 October 1796 – 26 October 1872), cared for the elder Goethe until his death in 1832. August and Ottilie had three children: Walther, Freiherr von Goethe (9 April 1818 – 15 April 1885), Wolfgang, Freiherr von Goethe (de) (18 September 1820 – 20 January 1883) and Alma von Goethe (de) (29 October 1827 – 29 September 1844). Christiane von Goethe died in 1816.

The next work, his epic closet drama Faust, was completed in stages. The first part was published in 1808 and created a sensation. Goethe finished Faust Part Two in the year of his death, and the work was published posthumously. Goethe's original draft of a Faust play, which probably dates from 1773–74, and is now known as the Urfaust, was also published after his death.

In 1810, Goethe published his Theory of Colours, which he considered his most important work. In it, he contentiously characterized colour as arising from the dynamic interplay of light and darkness through the mediation of a turbid medium. In 1816, Schopenhauer went on to develop his own theory in On Vision and Colours based on the observations supplied in Goethe's book. After being translated into English by Charles Eastlake in 1840, his theory became widely adopted by the art world, most notably J. M. W. Turner. Goethe's work also inspired the Philosopher Ludwig Wittgenstein, to write his Remarks on Colour. Goethe was vehemently opposed to Newton's analytic treatment of colour, engaging instead in compiling a comprehensive rational description of a wide variety of colour phenomena. Although the accuracy of Goethe's observations does not admit a great deal of criticism, his aesthetic approach did not lend itself to the demands of analytic and mathematical analysis used ubiquitously in modern Science. Goethe was, however, the first to systematically study the physiological effects of colour, and his observations on the effect of opposed colours led him to a symmetric arrangement of his colour wheel, 'for the colours diametrically opposed to each other... are those which reciprocally evoke each other in the eye. (Goethe, Theory of Colours, 1810). In this, he anticipated Ewald Hering's opponent colour theory (1872).

In politics, Goethe was conservative. At the time of the French Revolution, he thought the enthusiasm of the students and professors to be a perversion of their Energy and remained skeptical of the ability of the masses to govern. Likewise, he did not oppose the War of Liberation (1813–15) waged by the German states against Napoleon, and remained aloof from the patriotic efforts to unite the various parts of Germany into one nation. Although often requested to write poems arousing nationalist passions, Goethe would always decline. In old age, he explained why this was so to Eckermann:

The first operatic version of Goethe's Faust, by Louis Spohr, appeared in 1814. The work subsequently inspired operas and oratorios by Schumann, Berlioz, Gounod, Boito, Busoni, and Schnittke as well as symphonic works by Liszt, Wagner, and Mahler. Faust became the ur-myth of many figures in the 19th century. Later, a facet of its plot, i.e., of selling one's soul to the devil for power over the physical world, took on increasing literary importance and became a view of the victory of Technology and of industrialism, along with its dubious human expenses. In 1919, the world premiere complete production of Faust was staged at the Goetheanum.

In the decades which immediately followed its publication in 1816, Italian Journey inspired countless German youths to follow Goethe's Example. This is pictured, somewhat satirically, in George Eliot's Middlemarch.

In 1821 Goethe's friend Carl Friedrich Zelter introduced him to the 12 year old Felix Mendelssohn. Goethe, now in his seventies, was greatly impressed by the child, leading to perhaps the earliest confirmed comparison with Mozart in the following conversation between Goethe and Zelter:

Goethe also popularized the Goethe barometer using a principle established by Torricelli. According to Hegel, "Goethe has occupied himself a good deal with meteorology; barometer readings interested him particularly... What he says is important: the main thing is that he gives a comparative table of barometric readings during the whole month of December 1822, at Weimar, Jena, London, Boston, Vienna, Töpel... He claims to deduce from it that the barometric level varies in the same proportion not only in each zone but that it has the same variation, too, at different altitudes above sea-level".

After 1793, Goethe devoted his endeavours primarily to literature. By 1820, Goethe was on amiable terms with Kaspar Maria von Sternberg. In 1823, having recovered from a near fatal heart illness, Goethe fell in love with Ulrike von Levetzow whom he wanted to marry, but because of the opposition of her mother he never proposed. Their last meeting in Carlsbad on 5 September 1823 inspired him to the famous Marienbad Elegy which he considered one of his finest works. During that time he also developed a deep emotional bond with the Polish Pianist Maria Agata Szymanowska.

Mendelssohn was invited to meet Goethe on several later occasions, and set a number of Goethe's poems to music. His other compositions inspired by Goethe include the overture Calm Sea and Prosperous Voyage (Op. 27, 1828), and the cantata Die erste Walpurgisnacht (The First Walpurgis Night, Op. 60, 1832).

In 1832, Goethe died in Weimar of apparent heart failure. His last words, according to his Doctor Carl Vogel, were, Mehr Licht! (More light!), but this is disputed as Vogel was not in the room at the moment Goethe died. He is buried in the Ducal Vault at Weimar's Historical Cemetery.

Goethe wrote of both boys and girls: "I like boys a lot, but the girls are even nicer. If I tire of her as a girl, she'll play the boy for me as well" (Goethe, 1884). Goethe also defended pederasty: "Pederasty is as old as humanity itself, and one can therefore say that it is natural, that it resides in nature, even if it proceeds against nature. What culture has won from nature will not be surrendered or given up at any price."

It was to a considerable degree due to Goethe's reputation that the city of Weimar was chosen in 1919 as the venue for the national assembly, convened to draft a new constitution for what would become known as Germany's Weimar Republic.

The literary estate of Goethe in the Goethe and Schiller Archives was inscribed on UNESCO's Memory of the World Register in 2001 in recognition of its historical significance.

During his Italian journey, Goethe formulated a theory of plant metamorphosis in which the archetypal form of the plant is to be found in the leaf – he writes, "from top to bottom a plant is all leaf, united so inseparably with the Future bud that one cannot be imagined without the other". In 1790, he published his Metamorphosis of Plants. As one of the many precursors in the history of evolutionary thought, Goethe wrote in Story of My Botanical Studies (1831):

Goethe was also a cultural force, who argued that the organic nature of the land moulded the people and their customs—an argument that has recurred ever since. He argued that laws could not be created by pure rationalism, since geography and history shaped habits and patterns. This stood in sharp contrast to the prevailing Enlightenment view that reason was sufficient to create well-ordered societies and good laws.

That change later became the basis for 19th-century thought: organic rather than geometrical, evolving rather than created, and based on sensibility and intuition rather than on imposed order, culminating in, as Goethe said, a "living quality", wherein the subject and object are dissolved together in a poise of inquiry. Consequently, Goethe embraced neither teleological nor deterministic views of growth within every organism. Instead, his view was that the world as a whole grows through continual, external, and internal strife. Moreover, Goethe did not embrace the mechanistic views that contemporaneous science subsumed during his time, and therewith he denied rationality's superiority as the sole interpreter of reality.