Huber first got into professional wrestling as a backyard Wrestler, performing under the ring name Huberboy #2 with the likes of Colin Delaney and his real-life brother, who worked as Huberboy #1. Huber was eventually formally trained by Kirby Marcos and Rik Matrix in Rochester, New York, and Tony Mamaluke in Schenectady, New York, and made his debut for Roc City Wrestling (RCW) in late 2002, working under a mask as Huberboy #2. He eventually unmasked while still using the Huberboy #2 name. During 2003, Huber began working as Brodie Lee for Rochester Pro Wrestling (RPW). He came up with the name Brodie Lee from the movie Mallrats by combining the names of actor Jason Lee and his character Brodie Bruce. Huber cites Rick Rude, Jake Roberts, and Big Show as his influences. Throughout his time in RPW, which was later renamed to NWA Upstate and then again to NWA New York, Lee went on to win multiple championships including the heavyweight championship on three separate occasions, the tag team championship once and the television championship once, which he also proceeded to unify with the Kayfabe Dojo Championship. Huber has described his original "The Right Stuff" gimmick as him "just having fun" and "being a cruiserweight".

Lee made his debut for Syracuse, New York-based Squared Circle Wrestling (2CW) on August 20, 2007, teaming with Colin Olsen, as a replacement tag team partner for Jimmy Olsen, in a tag team match, where they were defeated by the Wyld Stallyns. Lee started off as a heel aligned with the rival promotion NWA Upstate. Lee started becoming popular after a July 26, 2008, post–match incident in Binghamton, New York that ended with him punching out a fan in the parking lot. Lee was in storyline suspended from 2CW over the incident. He returned on October 24 to a huge ovation, although he was still a heel, leading NWA Upstate to a victory in an eight-man tag team main event. He officially became a Babyface starting April 2009 when the rivalry between 2CW and NWA Upstate had subsided. Lee then started a friendly rivalry with Slyck Wagner Brown that saw both men trade wins in singles matches on June 6 and September 19, 2009. Lee defeated Brown in a rubber match on February 19, 2010, and then again in a two-out-of-three falls match on April 3, 2010, to end the feud. Lee challenged Jason Axe for the 2CW Heavyweight Championship on June 20, 2010, but lost due to outside interference. Lee defeated Isys Ephex on July 10 in a number one contender match to earn another shot at the title and, on August 22 in Watertown, New York, defeated Jason Axe to win the 2CW Heavyweight Championship for the first time. Lee made a successful first defense of the title against the former champion, Jason Axe, in an "I Quit" match in Binghamton, New York, on September 24, 2010. Lee lost the title to Slyck Wagner Brown on November 19, 2010, in Elmira, New York. Lee regained the title on April 13, 2012, in a four-way match with Jay Freddie, Slyck Wagner Brown and Kevin Steen, who stole the championship belt after the match. The following night, with the title belt still in Steen's possession, Lee successfully defended the 2CW Heavyweight Championship in another four-way match against Jason Axe, Jay Freddie and Matt Milan and afterwards relinquished it, as he had signed with WWE and would be contractually unable to defend it in the Future.

Lee made his debut for Ring of Honor (ROH) on October 25, 2008, aligning himself with The Age of the Fall and helping the group's leader Jimmy Jacobs to defeat Austin Aries in an Anything Goes match. Lee then teamed with fellow Age of the Fall member Delirious and defeated Cheech and Cloudy in a tag team match, before ending the night by attacking Necro Butcher, with whom the stable was feuding, after his match with Go Shiozaki. On November 7, Lee's match with Necro Butcher ended in a disqualification, when the rest of The Age of the Fall attacked his opponent. Lee and Necro Butcher had a rematch under Anything Goes rules on February 27, 2009, which Necro won. In March, Delirious turned on The Age of the Fall and on May 30 he defeated Lee in his final ROH match.

Lee made his debut for Jersey All Pro Wrestling (JAPW) on March 28, 2009, as a member of The Hillbilly Wrecking Crew, along with Necro Butcher and Trevor Murdoch. On August 1, Lee and Necro defeated the Garden State Gods (Corvis Fear and Myke Quest) to win the JAPW Tag Team Championship. On January 23, 2010 at JAPW's 12th Anniversary Show, Lee and Necro lost the title to Da Heavy Hitters (Havok and Monsta Mack) in a three-way tag team match, which also included The H8 Club (Nate Hatred and Nick Gage). On March 20, Lee got to challenge for the JAPW Heavyweight Championship, but was defeated by the defending champion Dan Maff and, after the match, Nick Gage attacked Maff and joined The Hillbilly Wrecking Crew, replacing Murdoch, who had left the company. On May 22, Lee and Necro faced Maff and the JAPW New Jersey State Champion Charlie Haas in a tag team match, where they put their JAPW careers on the line against the titles of their opponents. In the end, Lee managed to pin Haas, after Maff had turned on him, to become the new JAPW New Jersey State Champion. On October 23, 2010, Lee challenged Dan Maff for the JAPW Heavyweight Championship in a Champion vs. Champion match, but was defeated. On November 20, Lee first successfully defended the New Jersey State Championship against Eddie Kingston and then defeated Dan Maff, Nick Gage and Azrieal in a Championship Scramble to win the JAPW Heavyweight Championship for the first time, unifying the two titles. Lee made his first JAPW Heavyweight Championship defense on December 11, during the Anniversary weekend, defeating Rhino with help from Nick Gage. On December 30, 2011, JAPW announced that Lee, who had not made an appearance for the promotion in nine months, had been stripped of the JAPW Heavyweight Championship.

On December 21, 2010, Lee made his debut for Japanese promotion Dragon Gate (DG) in Tokyo, where he, representing The Warriors stable, defeated Kzy. The Warriors stable turned heel on January 14, 2011, when they attacked Masato Yoshino and World-1, aligning themselves with Naruki Doi's group, though Lee himself was not present, as he was snowed in and could not make the show. The following day, Lee made his return to DG as a member of the new top heel group, in a match, where he, Gamma and Genki Horiguchi defeated Yamato, Kagetora and Diablo. On January 18, the new group was named Blood Warriors.

Huber is married to fellow professional Wrestler Synndy. He has two sons, born in January 2012 and December 2017.

When FCW was rebranded as NXT Wrestling in August 2012, Harper made his television debut on the November 7 NXT as a follower of Bray Wyatt, who introduced Harper as the "first son" of The Wyatt Family. The Wyatt Family later also came to include Wyatt's "second son" Erick Rowan, with whom Harper formed a tag team. The two defeated Percy Watson and Yoshi Tatsu in their first match together on the January 9, 2013, NXT. On the January 23 NXT, Harper and Rowan again defeated Watson and Tatsu in the opening round of the NXT Tag Team Championship tournament. Following a win over Bo Dallas and Michael McGillicutty in the semi-finals with Wyatt's interference, Harper and Rowan were defeated in the finals of the tournament by Adrian Neville and Oliver Grey. Harper defeated Neville on the March 20 NXT. On the May 2 NXT, Harper and Rowan won a triple threat elimination tag match by last pinning Neville. On the May 8 NXT (taped May 2), Harper and Rowan defeated Neville and Bo Dallas, filling in for the injured Grey, to win the NXT Tag Team Championship. After retaining the title against Corey Graves and Kassius Ohno on the June 5 NXT, Harper and Rowan lost the NXT Tag Team Championship to Neville and Graves on the July 17 NXT (taped June 20).

From the May 27 Raw, WWE aired vignettes promoting the upcoming debut of the Wyatt Family. The vignettes showed the Wyatt Family's backwoods origins. On the July 8 Raw, the Wyatt Family made their debut by assaulting Kane. Harper made his WWE in-ring debut on the July 26 SmackDown, where he and Rowan defeated Tons of Funk (Brodus Clay and Tensai). Over the next few months, Harper and Rowan went on a winning streak over many teams, until Cody Rhodes and Goldust handed them their first loss on the October 11 SmackDown. After the Wyatt Family started feuding with CM Punk and Daniel Bryan, Harper wrestled two singles matches, losing to Punk on the November 4 Raw and to Bryan via disqualification on the November 8 SmackDown. In early 2014, The Wyatt Family feuded with The Shield, defeating them at Elimination Chamber, while also supporting Bray Wyatt in his feud with John Cena through WrestleMania XXX. Through Wyatt's feud with Cena, Harper and Rowan also started their own feud with the WWE Tag Team Champions The Usos (Jey Uso and Jimmy Uso), who supported Cena in the feud. Harper and Rowan went on to unsuccessfully challenge the Usos for the WWE Tag Team Championship at Money in the Bank and in a two out of three falls match at Battleground.

Beginning on September 29, vignettes were shown of Harper and Rowan being "set free" by Wyatt, marking the dissolution of the Wyatt Family and the transition of its members into singles competition. After a further series of video vignettes aimed at Dolph Ziggler, Harper made his return to TV during the closing moments of the November 10 Raw, throwing an unconscious Ziggler at Triple H and Stephanie McMahon's feet and expressing his Desire to join their team at Survivor Series. The following week on Raw, Harper officially joined Team Authority. Immediately after, Harper was awarded an impromptu match for the WWE Intercontinental Championship against Dolph Ziggler, which Harper won to capture his first title in WWE. At Survivor Series, Harper was eliminated by Ziggler. As punishment for his affiliation with The Authority, Harper was forced to defend the Intercontinental Championship against Dean Ambrose on the November 24 Raw and successfully retained the title after getting himself disqualified. Harper lost the title back to Ziggler in a ladder match at TLC: Tables, Ladders and Chairs, his reign ending at 27 days, and failed to regain the title in a rematch on the December 22 Raw. On January 25, 2015, Harper entered the Royal Rumble match at No. 4, and was eliminated by Bray Wyatt. Beginning in early March, Harper was involved into a storyline where he was one of many Wrestlers stealing Bad News Barrett's Intercontinental Championship belt from Barrett and each other. This led to a seven-man ladder match for the title on March 29 at WrestleMania 31, which was won by Daniel Bryan. The match led to a new feud between Harper and Dean Ambrose, with Harper losing a Chicago Street Fight between the pair at Extreme Rules. On the April 27 Raw, Harper took part in the 2015 King of the Ring tournament, but eliminated by Neville in the first round.

The Wyatt Family then got involved in a feud with Kane and The Undertaker, which built to a tag team match on November 22 at Survivor Series, where the two defeated Harper and Wyatt. The next night on Raw, Harper teamed with Wyatt again to defeat The Dudley Boyz, igniting a new feud. Over the next weeks, Tommy Dreamer and Rhyno joined The Dudley Boyz in the feud, leading to an eight-man tag team tables match at TLC: Tables, Ladders and Chairs on December 13, where Harper, Wyatt, Rowan and Strowman were victorious. On January 24, 2016, Harper competed in the Royal Rumble with fellow Wyatt Family members and he was eliminated by Brock Lesnar, but returned to the ring later on with the Wyatts to eliminate Lesnar. On March 21, Harper suffered a knee injury during a dark match onRaw, sidelining him for five to six months. After getting an MRI, it was revealed that he had dislocated his patella and tore his medial patellofemoral ligament. Because of his injury, Harper was not drafted to either Raw or SmackDown in the 2016 WWE draft.

During the 2017 Royal Rumble on January 29, Harper entered as number 25, attacking both Wyatt and Orton and eliminating Apollo Crews, before being eliminated by Goldberg. Over the next two weeks, Harper cemented his face turn by coming to WWE Champion John Cena's aid in his confrontations with Wyatt and Orton on SmackDown. At Elimination Chamber on February 12, Harper was defeated by Orton in a singles match. Due to Royal Rumble winner Orton refusing to face Wyatt for the WWE Championship at WrestleMania 33, a battle royal was set up on the February 21 SmackDown to determine a new number one contender, which saw Harper and AJ Styles become the co-winners by eliminating each other at the same time, setting up a singles match between the two for the following week, where Styles was victorious. After a month of absence, Harper returned with a new look on the March 28 episode of SmackDown, losing to Bray Wyatt. On April 2 on the WrestleMania 33 kickoff show, Harper took part in the André the Giant Memorial Battle Royal, from which he was eliminated by Titus O'Neil. A couple days later on SmackDown, Harper aided Orton to fight off Bray Wyatt and a returning Erick Rowan with the two defeating Wyatt and Rowan in a tag team match later on in the main event. The rivalry between Harper and Rowan was seemingly ended at Backlash on May 21, where Harper defeated Rowan.