Jorge Horacio Brito was born to an upper-class family in Buenos Aires in 1952.

ADEBA was founded in 1972 and is part of the G-6 Group, which unites the main Argentine Business entities such as the Argentine Industrial Union, the Buenos Aires Stock Exchange, the Argentine Construction Chamber, the Argentine Chamber of Commerce, and the Argentine Rural Society. The Group organizes debates related with domestic economy and development.

He founded Anglia, a brokerage firm, in 1976 and, in 1985, purchased a competing brokerage, Financiera Macro, forming Macro Bank (Banco Macro). He was named Chairman of the Board of Directors in June 1988 while Macro Bank grew steadily with the acquisition of numerous provincial banks privatised during the 1990s, including the Bank of Salta and of neighbouring Tucumán Province.

Inversora Juramento Inc., founded in 1990, is one of the leading farming-cattle companies in the Argentine Northern Region. Because of its high quality standards, it is considered a model company. It is located in the town of Joaquín V. González, Salta, where it owns 67,000 hectares of field and 54,000 heads of cattle. Its core activity is the manufacture and trading of beef. Moreover, the company sows around 12,600 hectares per year. 8,000 hectares are soya fields. It also sows sorghum, alfalfa and corn, which are used to feed the cattle.

Brito became chairman of the Argentine Banking Association (ADEBA) on April 8, 2003 until 2016, when was succeed by Daniel Llambías, chairman of Grupo Financiero Galicia owner of Banco Galicia. On 2017 He was replaced by Jorge Pablo Brito, Brito's son and Director of Macro Bank.

Brito serves as chairman of the boards of Directors of Banco del Tucuman S.A., Inversora Juramento S.A., and Banco Privado de Inversiones S.A. He is the founder and CEO of Banco Macro, and oversees Investments in diverse activities such as real estate (through Vizora), and in farming and cattle raising through Inversora Juramento Inc., Frigoríficos Bermejo Inc. cold storages and Cabañas Juramento Inc. butcher shops. He owns a share of Genneia Inc., an Energy sector company. He also serves as chairman of the board of Directors of YPF, long the largest petroleum Producer and refiner in Argentina. Brito was among those who expressed interest in the purchase of 20% of the Madrid-based Repsol's ownership of the former state oil concern, when these shares were offered for sale in 2007.

Between 2012 and 2014, Jorge Horacio Brito was the President of the Latin America Banking Federation (FELABAN), a non-profit organization whose aim is to ease and promote relationships between all Latin American financing entities.

In 2016 he won the Fortuna Lifetime Achievements Awards because of his trajectory in Argentinean Business community.

In 2017 Forbes Magazine placed Nº. 1.567 of the World's Billionaires list. In Argentina, he is the 7th richest businessman of the country.

Brito’s companies of farming and cattle raising activities involve cow breeding and meat industrialization and commercialization, and to a lesser extent, agricultural sowing activities, mainly in soy. Inversora Juramento Inc. is in charge of cattle breeding. Frigoríficos Bermejo cold storage is engaged in industrial slaughtering and meat industrialization that reaches the consumer through Cabañas Juramento Inc. butcher shops.