Shirley's other credits include playing the female lead opposite John Hannah in 'Dr Jekyll & Mr Hyde' (Working Title), The Office Christmas specials and Twenty Thousand Streets Under the Sky. She has also worked extensively in theatre at the Royal National Theatre and Royal Court. In June 2009, Shirley co-hosted the BBC Two show Something for the Weekend with Tim Lovejoy, standing in for Amanda Hamilton who was on maternity leave. She has since appeared on "Sunday Brunch" and regularly on magazine show "The Wright Stuff" she featured in the Pencil Full of Lead video by Scottish singer Paolo Nutini.

Shirley played the role of "Louise" in the 2012 Lionsgate feature film Riot about the London Riots. In February 2013, she starred as Susie Browning in Run for Your Wife with Judi Dench and Danny Dyer. In the film Girl on a Bicycle, directed by Jeremy Leven, Shirley plays 'Marta' opposite Paddy Considine. She portrayed Ali in the independent film "Everyone's Going to Die" as well as the role of 'Lydia' in the 6 part series 'Self Centered' for Pollibee Pictures. She played "Stella Stone & Gemma" in Royal National Theatre play about the phone hacking scandal "Great Britain" directed by Nick Hytner. Shirley has also finished a run at The Theatre Royal Haymarket in One Man, Two Guvnors as "Pauline" after its international tour clocking up over 650 performances. Shirley works extensively for BBC Radio 4, including three series of comedy "House on Fire" written by Chris Sussmann and long running series "A Small Town Murder". Her most recent TV appearance was in Sky drama series "The Marriage of Reason and Squalor" directed by "The Chapman Brothers".