Reed's appearances in erotica have included posing for Playboy Magazine in December 1996, in a group pictorial of women from the television series Women: Stories of Passion, and appearing in direct-to-video (DTV) movies like Secrets of a Chambermaid. In The Erotic Thriller in Contemporary Cinema, Linda Ruth Williams cited Reed and Delia Sheppard as examples of actresses who worked "...in B-scale erotic thrillers at the fringes of Hollywood, the obvious trajectory for a strip-circuit veteran (DTV divas Kira Reed and Delia Sheppard both started as showgirls.)" The book also reproduces a quote from an article at Playboy.com, with Williams again making specific reference to Reed. "Video may have killed the radio star, but it proved a real boon to Playmates in the Eighties, who played a not insignificant role in that decade's video revolution"

Reed also worked in adult entertainment with her first husband, Dan Anderson. They took part in Juli Ashton's Essentially Fresh; which was subsequently featured in Ashton's Wicked Pictures production Basically Becca (2001). The couple marketed photos, home movies and live performances through an adult website called MarriedCouple.com. In 2001, Adult Industry News reported that the couple intended for their website material to be available exclusively to MarriedCouple.com members while they continued performing "...in a variety of more softcore and even mainstream projects for the rest of the public."

She is President of The RHL Group, an event-production, publication and entertainment company founded by Robert Lorsch, producing charity events and television programming. In December 2012, RHL published Reed's Score: How to Win the Girl of Your Dreams.

In addition to appearances as "Herself" and/or on behalf of organizations she works with, the list of Reed's credits includes Producer, Writer, Director, and stunt person. She has appeared in movies, including starring roles in Red Shoe Diaries and The Price Of Desire, and on network television, on shows such as ER, NYPD Blue and The War at Home. She was a reporter and Producer on Playboy TV's series Sexcetera, produced the second season of the Naked Happy Girls series and was both a Writer and supervising Producer on Playboy's hit travel/reality show 69 Sexy Things 2 Do Before You Die. Reed has worked as the backstage host for the Daytime Emmy Awards and a reporter for the Hollywood Christmas Parade. She was featured on Bravo Interior Therapy with Jeff Lewis with her husband Robert Lorsch. Reed joined the cast of the Emmy nominated The Bay in 2014 and its producing team soon thereafter. The web series won a Daytime Emmy for Outstanding Drama Series - New Approaches in 2015 and Reed herself took home an Emmy as a Producer on the show in 2016 and again in 2017.

Reed's marriage to Anderson lasted five years. She is now married to Robert Lorsch. Reed is a supporter of the mental health awareness organization The Thalians. She also supports Shelter Hope Pet Shop, a Thousand Oaks animal rescue group that puts dogs that might otherwise face euthanasia up for adoption instead. She appears as Ms. June in Shelter Hope's 2015 fundraising calendar.

In 2018, Kira received her first acting Emmy nomination as Outstanding Supporting Actress in a Digital Daytime Drama Series for her role of "Jo Connors" on The Bay.