In 2005, The Naked Brothers Band: The Movie won the audience award for a family feature film at the Hamptons International Film Festival. Of Hecht's attendance, he said, "I could see there was an audience for this. They're real kids, real brothers, making real music."

In October 2006, online videos from their Nickelodeon website had been played over 11 million times. Moreover, before the show's debut, "a fan recognized Nat and Alex in a Florida hotel. She sent them a note: 'Are you the Naked Brothers?' 'They were so excited,' Draper recalled. 'The show hasn't even aired yet and now walking down the streets kids are calling out their names. They can't believe it.' "

According to a 2007 PRNewswire article, the show "quickly became one of the top programs for tweens on television". The series is in a popular category of children's TV shows, along with Disney Channel's Hannah Montana and Cory in the House. By October 2007, Nick.com's message boards had 5.3 million pages viewed, causing online madness. The show has three video games online that have been played about 24 million times. Moreover, fans have downloaded over 800 thousand podcasts.

Draper received a Writers Guild Award nomination for the episode "Nat is a Stand-Up Guy" in the section of Children's Episodic and Specials in 2008. The following year, in 2009, the TV movie Polar Bears won Draper a WGA for Children's Script — Long Form or Special; it was the only one nominated in the category. In 2007, Nat was nominated for Best TV Actor at the Nickelodeon Kids' Choice Awards in the United Kingdom. Moreover, the adult Wolff and his sons received a Broadcast Music, Inc. Cable Award for their work on the show's music. In 2008, the series' cast performed at the KCAs in United States; the following year, Nat was nominated for Favorite TV Actor.

For all ages, the premiere of the season one TV movie "Battle of the Bands" was quite successful, garnering a viewership of exactly 3.8 million. The second season TV movie "Sidekicks" debuted to a total of 3.6 million viewers, with the season's finale TV movie "Polar Bears" drawing 1.7 million viewers for children aged 6–11; the latter was the second most watched show for the week in that age group. The series flourished the most with the airing of the season three TV movie "Mystery Girl", producing a viewership of 4 million. A month later, the TV movie "Operation Mojo" was broadcast to an audience of 2.8 million viewers. When the season three TV special "Valentine Dream Date" aired, it was also successful; exactly 3.2 million viewers watched it.

Despite the show's prosperity—in terms of its viewership ratings, as it came close to wrap up filming for the third season, network bosses urged the family to lengthen the season from 13 episodes to 60. Nevertheless, prior agreements had already been made between Draper, her husband and the staff at Nickelodeon that shooting would not interfere with the boys' school schedule. Network executives chose no longer to conform to the family's demands, prompting Draper and Wolff to cancel the series in mid-2009. Of the cancellation, no formal announcement had been made by either the family or network until Nat disclosed the incident to the press in 2013.