The Dick Van Dyke Show: Carl Reiner reprised the role of Alan Brady from the 1960s sitcom (a series acknowledged as an inspiration for Mad About You). The episode made several references to the older show, such as Jamie at one point crying and whining "Oh, Paul!" – a signature move by Mary Tyler Moore's character Laura Petrie. Ten episodes earlier, Paul almost trips over a box and says, "Get me, I'm Dick Van Dyke."

Mad About You is an American sitcom that aired on NBC from September 23, 1992 to May 24, 1999. The show starred Paul Reiser and Helen Hunt as a married couple in New York City. In April 2018, it was announced that Sony Pictures Television will revive the show with the two lead actors to reprise their roles.

Friends (owned by Warner Bros. Television): Lisa Kudrow played the recurring role of Ursula, a flaky waitress at Riff's Bar, a local restaurant that Paul and Jamie frequented. Kudrow went on to star in the NBC sitcom Friends, playing the also somewhat flaky character of Phoebe Buffay, and for a time both series shared the same Thursday night line-up. While not originally intended, the characters of Ursula and Phoebe were later found to be identical twin sisters. In a Friends episode ("The One With The Two Parts", 1st Season), as part of a night of NBC sitcom crossovers, Jamie and Fran walk into Central Perk and mistake Phoebe for Ursula. Hunt and Kenzle were not identified on screen as Jamie and Fran. In the season three episode "Pandora's Box", Jamie causes a citywide power blackout in New York City, and the effects of the blackout are seen in the Friends episode, "The One with the Blackout", and there was also a blackout in the episode "Birthday in the Big House" of the short-lived NBC sitcom Madman of the People, which leaves open the possibility that the characters from this program may also exist in the same universe as the characters of Mad About You. All three episodes originally aired during the evening of November 3, 1994, alongside a Seinfeld episode which did not incorporate the blackout premise.

In 1997, Atlantic Records released a Mad About You Soundtrack. The Soundtrack from and inspired by the sitcom, is composed of fun and sentimental songs and clips from the show. The tracks are organized chronologically marking the milestones of the couple's relationship. The album is bookended by the two versions of Paul Reiser's song "Final Frontier"—the first track is the classic version used in the show's opening, and the last track is Anita Baker's jazzy, full-length rendition, with Reiser on keyboard. The 21 tracks are as follows:

In February 2010, Shout! Factory acquired the rights to release the remaining seasons of Mad About You on DVD. They subsequently released seasons 4 and 5 on DVD.

On August 27, 2013, it was announced that Mill Creek Entertainment had acquired the rights to various television series from the Sony Pictures library including Mad About You. They subsequently re-released the first and second seasons on DVD on August 5, 2014.

A Chinese adaptation will air on Dragon TV from January 4, 2016. An Argentine remake titled Loco por vos will air on Telefe from August, 2016.