Musgrave soon acquired attention from casting Directors and talent agencies after her arrival in Los Angeles. Within a year, she appeared on the television show CSI: Crime Scene Investigation. Her big break came when she landed the role of Chelsea Benson on the daytime drama Days of Our Lives, appearing on the series from 2004 to 2005. In addition, Musgrave appeared on The King of Queens in 2005. Later that year, she debuted on South of Nowhere as Ashley Davies. The character has become "an icon among teenagers across America". The role "catapulted [Musgrave] to another level of fame among teenagers and young adults".

In 2007, Musgrave appeared opposite her South of Nowhere love interest Gabrielle Christian in web series Girltrash!. Musgrave portrayed Actress Misty Monroe; Christian played college graduate Colby Robson. In 2014, Musgrave and Christian reprised their roles in a new musical film called Girltrash: All Night Long by Angela Robinson (D.E.B.S.).

Musgrave has also starred in Dan's Detour of Life a webseries comedy written by the producers of That '70s Show. She portrayed Jessie Ford, a 15-year-old high school student dealing with her parents' abrupt divorce. In 2010 Musgrave was cast in a guest role on the television series 90210. She appeared in three episodes as Alexa, Gia's ex-girlfriend.

Musgrave has two sisters (one twin sister Jamie and one older sister Brianna), and enjoys playing volleyball, water polo and kickball. In her spare time, Musgrave spends time with South of Nowhere co-stars Gabrielle Christian, Maeve Quinlan, and Matt Cohen. Musgrave married Cohen in May 2011. Musgrave gave birth to the couple's first child, a son, on April 4, 2015. Musgrave is a frequent Runner, sings karaoke, writes her own poetry and paints collages.