She graduated from Raytown South High School in 1988. She is a graduate of Northwestern University, where she earned a bachelor's degree in journalism and became a member of the Delta Sigma Theta sorority. After she graduated from Northwestern in 1992, Brock Akil decided to put her career plans in journalism on hold to work as a manager at the Howard Street Gap in Chicago and look for opportunities to work within Chicago's entertainment industry. She decided to change careers after securing the role of Ms. Moore in the 1994 film With Honors. This role inspired Brock Akil to return to Los Angeles to start her career.

Brock Akil first began writing for television in 1994 writing for the critically acclaimed but short-lived Fox series South Central. In 1999, she served as supervising Producer and Writer on The Jamie Foxx Show after writing for Moesha for four seasons. In 2000, Brock Akil created and executive produced (along with Kelsey Grammer) another UPN series, Girlfriends. She also created and executive produced Girlfriends′ spin-off series, The Game. In 2009, Brock Akil became a consulting Producer and Writer for the ABC suburban sitcom Cougar Town. She is the creator of BET's Being Mary Jane, which premiered in 2013.

Brock Akil went straight to UPN and sold her idea for her hit series to the network. She shopped the series around to studios to start the filming process, but, even though the show sold to a major network, no filming company wanted to take the bait. She struck a deal with Kelsey Grammer, and his involvement with Paramount pictures was able to sign on as an executive Producer for the show. Girlfiends premiered on September 11, 2000, and became a part of UPN's Monday night prime time line up. Chronicling the life of Joan Clayton, played by Tracee Ellis Ross, and her four friends, the show ran for eight seasons, lasting through the production switch from UPN and the launch of the CW network. The show's two-part series finale aired on the CW on February 11, 2008.

Staci Robinson, Writer and author of Interceptions, filed a 40 million-dollar lawsuit against Brock Akil and the CW network, accusing Brock Akil of stealing the concept of her hit CW comedy series from her novel that was unpublished when she showed it to her in 2001. Robinson claimed she thought of the show first because her novel chronicles the life of Stefanie Porter, a senior studying law at UCLA, who ceases her hopes of becoming a Lawyer to support the dreams of her boyfriend, star football player Ricky Powers.

Following the launch of the CW network, Brock Akil created a spin-off series to her first show that follows the life of Joan's cousin, Melanie Barnett, played by Tia Mowry. She places her dreams of being a Doctor on hold and moves to San Diego to be a supportive backbone to her boyfriend, professional football player Derwin Davis, played by Pooch Hall. The series ran on the CW network for three seasons until its abrupt ending in 2009. The show was canceled for about two years until it was picked up by BET and began production in Atlanta. The Game brought in 7.7 million viewers in its Season 4 premier on BET. After adding six more seasons to the series, the network released a statement on its website stating that the show would conclude after production of the seventh and eighth seasons.

With an already established relationship with the BET network, Brock Akil worked alongside her husband to co-write and produce their first show on BET. Being Mary Jane, starring Gabrielle Union premiered July 2, 2013, and became the couple's first hour-long scripted show. The show chronicles the life of Mary Jane Paul, a successful news anchor, and attempts to address the statistic that within the black community 42 percent of successful women will never marry.

As of March 2017, Brock Akil left ICM Partners to join CAA.

Brock Akil met Salim Akil while working on the set of Moesha, and the two married in 1999. Salim also went on to establish a career in the industry as a television Director. The couple has two sons; their first son, Yasin Ali Akil, was born on April 16, 2004, and their second son, Nasir Lukmon Akil, was born on November 16, 2009. She and her husband, Salim, currently are practicing Sufi Muslims. The Akils created and executive produced a scripted superhero series, Black Lightning, based on DC Comics' Black Lightning series. The show premiered on January 16, 2018.