On both the paternal and maternal sides, the family had lost their property and fortunes through patriotic involvements in Polish national uprisings aimed at restoring Poland's independence (the most recent had been the January Uprising of 1863–65). This condemned the subsequent generation, including Maria, her elder sisters and her brother, to a difficult struggle to get ahead in life.

Maria Skłodowska was born in Warsaw, in the Russian partition of Poland, on 7 November 1867, the fifth and youngest child of well-known teachers Bronisława, née Boguska, and Władysław Skłodowski. The elder siblings of Maria (nicknamed Mania) were Zofia (born 1862, nicknamed Zosia), Józef (born 1863, nicknamed Józio), Bronisława (born 1865, nicknamed Bronia) and Helena (born 1866, nicknamed Hela).

The Father was eventually fired by his Russian supervisors for pro-Polish sentiments, and forced to take lower-paying posts; the family also lost money on a bad investment, and eventually chose to supplement their income by lodging boys in the house. Maria's mother Bronisława operated a prestigious Warsaw boarding school for girls; she resigned from the position after Maria was born. She died of tuberculosis in May 1878, when Maria was ten years old. Less than three years earlier, Maria's oldest sibling, Zofia, had died of typhus contracted from a boarder. Maria's Father was an atheist; her mother a devout Catholic. The deaths of Maria's mother and sister caused her to give up Catholicism and become agnostic.

When she was ten years old, Maria began attending the boarding school of J. Sikorska; next she attended a gymnasium for girls, from which she graduated on 12 June 1883 with a gold medal. After a collapse, possibly due to depression, she spent the following year in the countryside with relatives of her Father, and the next year with her Father in Warsaw, where she did some tutoring. Unable to enroll in a regular institution of higher education because she was a woman, she and her sister Bronisława became involved with the clandestine Flying University (sometimes translated as Floating University), a Polish patriotic institution of higher learning that admitted women students.

Because of their levels of radioactive contamination, her papers from the 1890s are considered too dangerous to handle. Even her cookbook is highly radioactive. Her papers are kept in lead-lined boxes, and those who wish to consult them must wear protective clothing. In her last year, she worked on a book, Radioactivity, which was published posthumously in 1935.

In late 1891, she left Poland for France. In Paris, Maria (or Marie, as she would be known in France) briefly found shelter with her sister and brother-in-law before renting a garret closer to the university, in the Latin Quarter, and proceeding with her studies of physics, chemistry, and mathematics at the University of Paris, where she enrolled in late 1891. She subsisted on her meager resources, suffering from cold winters and occasionally fainting from hunger.

She was known for her honesty and moderate life style. Having received a small scholarship in 1893, she returned it in 1897 as soon as she began earning her keep. She gave much of her first Nobel Prize money to friends, family, students, and research associates. In an unusual decision, Curie intentionally refrained from patenting the radium-isolation process, so that the scientific community could do research unhindered. She insisted that monetary gifts and awards be given to the scientific institutions she was affiliated with rather than to her. She and her husband often refused awards and medals. Albert Einstein reportedly remarked that she was probably the only person who could not be corrupted by fame.

In 1895, Wilhelm Roentgen discovered the existence of X-rays, though the mechanism behind their production was not yet understood. In 1896, Henri Becquerel discovered that uranium salts emitted rays that resembled X-rays in their penetrating power. He demonstrated that this radiation, unlike phosphorescence, did not depend on an external source of Energy but seemed to arise spontaneously from uranium itself. Influenced by these two important discoveries, Curie decided to look into uranium rays as a possible field of research for a thesis.

In 1897, her daughter Irène was born. To support her family, Curie began teaching at the École Normale Supérieure. The Curies did not have a dedicated laboratory; most of their research was carried out in a converted shed next to the School of Physics and Chemistry. The shed, formerly a medical school dissecting room, was poorly ventilated and not even waterproof. They were unaware of the deleterious effects of radiation exposure attendant on their continued unprotected work with radioactive substances. The School did not sponsor her research, but she would receive subsidies from metallurgical and mining companies and from various organizations and governments.

Marie Curie's 1898 publication with her husband and their collaborator Gustave Bémont. for their discovery of radium and polonium was honored by a Citation for Chemical Breakthrough Award from the Division of History of Chemistry of the American Chemical Society presented to the ESPCI Paris (Ecole supérieure de physique et de chimie industrielles de la Ville de Paris) in 2015.

In 1900, Curie became the first woman faculty member at the École Normale Supérieure, and her husband joined the faculty of the University of Paris. In 1902 she visited Poland on the occasion of her father's death.

In December 1903, the Royal Swedish Academy of Sciences awarded Pierre Curie, Marie Curie, and Henri Becquerel the Nobel Prize in Physics, "in recognition of the extraordinary services they have rendered by their joint researches on the radiation phenomena discovered by Professor Henri Becquerel." At first, the Committee intended to honour only Pierre Curie and Henri Becquerel, but one of the committee members and an advocate of women Scientists, Swedish Mathematician Magnus Goesta Mittag-Leffler, alerted her husband Piere to the situation, and after his complaint, Curie's name was added to the nomination. Marie Curie was the first woman to be awarded a Nobel Prize.

In December 1904, Curie gave birth to their second daughter, Ève. She hired Polish governesses to teach her daughters her native language, and sent or took them on visits to Poland.

Curie and her husband declined to go to Stockholm to receive the prize in person; they were too busy with their work, and Pierre Curie, who disliked public ceremonies, was feeling increasingly ill. As Nobel laureates were required to deliver a lecture, the Curies finally undertook the trip in 1905. The award money allowed the Curies to hire their first laboratory assistant. Following the award of the Nobel Prize, and galvanized by an offer from the University of Geneva, which offered Pierre Curie a position, the University of Paris gave him a professorship and the chair of physics, although the Curies still did not have a proper laboratory. Upon Pierre Curie's complaint, the University of Paris relented and agreed to furnish a new laboratory, but it would not be ready until 1906.

On 19 April 1906, Pierre Curie was killed in a road accident. Walking across the Rue Dauphine in heavy rain, he was struck by a horse-drawn vehicle and fell under its wheels, causing his skull to fracture. Curie was devastated by her husband's death. On 13 May 1906 the physics department of the University of Paris decided to retain the chair that had been created for her late husband and to offer it to Marie. She accepted it, hoping to create a world-class laboratory as a tribute to her husband Pierre. She was the first woman to become a professor at the University of Paris.

Curie's quest to create a new laboratory did not end with the University of Paris, however. In her later years, she headed the Radium Institute (Institut du radium, now Curie Institute, Institut Curie), a radioactivity laboratory created for her by the Pasteur Institute and the University of Paris. The initiative for creating the Radium Institute had come in 1909 from Pierre Paul Émile Roux, Director of the Pasteur Institute, who had been disappointed that the University of Paris was not giving Curie a proper laboratory and had suggested that she move to the Pasteur Institute. Only then, with the threat of Curie leaving, did the University of Paris relent, and eventually the Curie Pavilion became a joint initiative of the University of Paris and the Pasteur Institute.

In 1910, Curie succeeded in isolating radium; she also defined an international standard for radioactive emissions that was eventually named for her and Pierre: the curie. Nevertheless, in 1911 the French Academy of Sciences did not elect her to be a member by one or two votes. Elected instead was Édouard Branly, an Inventor who had helped Guglielmo Marconi develop the wireless telegraph.

International recognition for her work had been growing to new heights, and the Royal Swedish Academy of Sciences, overcoming opposition prompted by the Langevin scandal, honored her a second time, with the 1911 Nobel Prize in Chemistry. This award was "in recognition of her services to the advancement of chemistry by the discovery of the elements radium and polonium, by the isolation of radium and the study of the nature and compounds of this remarkable element." She was the first person to win or share two Nobel Prizes, and remains alone with Linus Pauling as Nobel laureates in two fields each. A delegation of celebrated Polish men of learning, headed by Novelist Henryk Sienkiewicz, encouraged her to return to Poland and continue her research in her native country. Curie's second Nobel Prize enabled her to persuade the French government into supporting the Radium Institute, built in 1914, where research was conducted in chemistry, physics, and Medicine. A month after accepting her 1911 Nobel Prize, she was hospitalised with depression and a kidney ailment. For most of 1912 she avoided public life but did spend time in England with her friend and fellow Physicist, Hertha Ayrton. She returned to her laboratory only in December, after a break of about 14 months.

In 1912, the Warsaw Scientific Society offered her the directorship of a new laboratory in Warsaw but she declined, focusing on the developing Radium Institute to be completed in August 1914, and on a new street named Rue Pierre-Curie. She was appointed Director of the Curie Laboratory in the Radium Institute of the University of Paris, founded in 1914. She visited Poland in 1913 and was welcomed in Warsaw but the visit was mostly ignored by the Russian authorities. The Institute's development was interrupted by the coming war, as most researchers were drafted into the French Army, and it fully resumed its activities in 1919.

During World War I, Curie recognised that wounded Soldiers were best served if operated upon as soon as possible. She saw a need for field radiological centres near the front lines to assist battlefield Surgeons. After a quick study of radiology, anatomy, and Automotive mechanics she procured X-ray equipment, vehicles, auxiliary generators, and developed mobile radiography units, which came to be popularly known as petites Curies ("Little Curies"). She became the Director of the Red Cross Radiology Service and set up France's first military radiology centre, operational by late 1914. Assisted at first by a military Doctor and by her 17-year-old daughter Irène, Curie directed the installation of 20 mobile radiological vehicles and another 200 radiological units at field hospitals in the first year of the war. Later, she began training other women as aides.

In 1915, Curie produced hollow needles containing "radium emanation", a colorless, radioactive gas given off by radium, later identified as radon, to be used for sterilizing infected tissue. She provided the radium from her own one-gram supply. It is estimated that over a million wounded Soldiers were treated with her X-ray units. Busy with this work, she carried out very little scientific research during that period. In spite of all her humanitarian contributions to the French war effort, Curie never received any formal recognition of it from the French government.

She was also an active member in committees of Polonia in France dedicated to the Polish cause. After the war, she summarized her wartime experiences in a book, Radiology in War (1919).

In 1920, for the 25th anniversary of the discovery of radium, the French government established a stipend for her; its previous recipient was Louis Pasteur (1822–95). In 1921, she was welcomed triumphantly when she toured the United States to raise funds for research on radium. Mrs. william Brown Meloney, after interviewing Curie, created a Marie Curie Radium Fund and raised money to buy radium, publicising her trip.

In 1921, U.S. President Warren G. Harding received her at the White House to present her with the 1 gram of radium collected in the United States. Before the meeting, recognising her growing fame abroad, and embarrassed by the fact that she had no French official distinctions to wear in public, the French government offered her a Legion of Honour award, but she refused. In 1922 she became a fellow of the French Academy of Medicine. She also travelled to other countries, appearing publicly and giving lectures in Belgium, Brazil, Spain, and Czechoslovakia.

In August 1922, Marie Curie became a member of the newly created International Committee on Intellectual Cooperation of the League of Nations. In 1923, she wrote a biography of her husband Pierre, entitled Pierre Curie. In 1925, she visited Poland, to participate in the ceremony that laid foundations for the Radium Institute in Warsaw. Her second American tour, in 1929, succeeded in equipping the Warsaw Radium Institute with radium; it was opened in 1932 and her sister Bronisława became its Director. These distractions from her scientific labours and the attendant publicity caused her much discomfort but provided resources needed for her work. In 1930, she was elected a member of the International Atomic Weights Committee where she served until her death.

Curie visited Poland for the last time in early 1934. A few months later, on 4 July 1934, she died at the Sancellemoz sanatorium in Passy, Haute-Savoie, from aplastic anemia believed to have been contracted from her long-term exposure to radiation.

Several works of art bear her likeness. In 1935, Michalina Mościcka, wife of Polish President Ignacy Mościcki, unveiled a statue of Marie Curie before Warsaw's Radium Institute. During the 1944 Second World War Warsaw Uprising against the Nazi German occupation, the monument was damaged by gunfire; after the war it was decided to leave the bullet marks on the statue and its pedestal. In 1955 Jozef Mazur created a stained glass panel of her, the Maria Skłodowska-Curie Medallion, featured in the University at Buffalo Polish Room.

Her name is included on the Monument to the X-ray and Radium Martyrs of All Nations, erected in Hamburg, Germany in 1936.

A number of biographies are devoted to her. In 1938 her daughter, Ève Curie, published Madame Curie. In 1987 Françoise Giroud wrote Marie Curie: A Life. In 2005 Barbara Goldsmith wrote Obsessive Genius: The Inner World of Marie Curie. In 2011 Lauren Redniss published Radioactive: Marie and Pierre Curie, a Tale of Love and Fallout.

Greer Garson and Walter Pidgeon starred in the 1943 U.S. Oscar-nominated film, Madame Curie, based on her life. More recently, in 1997, a French film about Pierre and Marie Curie was released, Les Palmes de M. Schutz. It was adapted from a play of the same name. In the film, Marie Curie was played by Isabelle Huppert.

Two museums are devoted to Marie Curie. In 1967, the Maria Skłodowska-Curie Museum was established in Warsaw's "New Town", at her birthplace on ulica Freta (Freta Street). Her Paris laboratory is preserved as the Musée Curie, open since 1992.

Curie's likeness also has appeared on banknotes, stamps and coins around the world. She was featured on the Polish late-1980s 20,000-złoty banknote as well as on the last French 500-franc note, before the franc was replaced by the euro. Curie themed postage stamps from Mali, the Republic of Togo, Zambia, and the Republic of Guinea actually show a picture of Susan Marie Frontczak portraying Curie in a 2001 picture by Paul Schroeder.

In 1995, she became the first woman to be entombed on her own merits in the Panthéon, Paris. The curie (symbol Ci), a unit of radioactivity, is named in honour of her and Pierre Curie (although the commission which agreed on the name never clearly stated whether the standard was named after Pierre, Marie or both of them). The element with atomic number 96 was named curium. Three radioactive minerals are also named after the Curies: curite, sklodowskite, and cuprosklodowskite. She received numerous honorary degrees from universities across the world. The Marie Skłodowska-Curie Actions fellowship program of the European Union for young Scientists wishing to work in a foreign country is named after her. In Poland, she had received honorary doctorates from the Lwów Polytechnic (1912),Poznań University (1922), Kraków's Jagiellonian University (1924), and the Warsaw Polytechnic (1926). In 1921, in the U.S., she was awarded membership in the Iota Sigma Pi women scientists' society.

Numerous locations around the world are named after her. In 2007, a metro station in Paris was renamed to honour both of the Curies. Polish nuclear research reactor Maria is named after her. The 7000 Curie asteroid is also named after her. A KLM McDonnell Douglas MD-11 (registration PH-KCC) is named in her honour.

As one of the most famous women Scientists to date, Marie Curie has become an icon in the scientific world and has received tributes from across the globe, even in the realm of pop culture. In a 2009 poll carried out by New Scientist, she was voted the "most inspirational woman in science". Curie received 25.1 per cent of all votes cast, nearly twice as many as second-place Rosalind Franklin (14.2 per cent).

On the first centenary of Marie Curie's second Nobel Prize in 2011, an allegorical mural was painted on the façade of her Warsaw birthplace. It depicts an infant Maria Skłodowska holding a test tube from which emanate the elements that she would discover as an adult: polonium and radium. Also in 2011, a new Warsaw bridge over the Vistula was named in her honor.

Several institutions bear her name, starting with the two Curie institutes – the Maria Skłodowska–Curie Institute of Oncology, in Warsaw; and the Institut Curie in Paris. She is the patron of Maria Curie-Skłodowska University, in Lublin, founded in 1944; and of Pierre and Marie Curie University (Paris VI), France's pre-eminent science university. In Britain, Marie Curie Cancer Care was organized in 1948 to care for the terminally ill.

Curie is the subject of the play False Assumptions by Lawrence Aronovitch, in which the ghosts of three other women Scientists observe events in her life. Curie has also been portrayed by Susan Marie Frontczak in her play Manya: The Living History of Marie Curie, a one-woman show performed in 30 US states and nine countries, by 2014.