Her debut took place in 1995 at the Theater of Musical Comedy. While still a student of Boris Shchukin Theatre Institute she was noticed by a film Director Tatyana Voronetskaya and was invited to star in the historical melodrama "The Model". Which participated in the competition program of the 18th Film Festival Kinotavr.

The following year, she was invited to play a starring role of Svetlana in the film "Blockhead" (Ohlamon) where you can hear her singing. The Actress became popular in 2008 after the release of a family saga "Dear people" on the TV channel Russia 1, in which she starred as Olga. The show was extended for another 200 episodes.

Since 2009 Marina was invited to be filmed abroad. Chinese Director Yu Xiao Gan offers Marina Orlova, a main role in the film "The Last Secrets of the Master"(猎人笔记之谜). Also one of the musical themes of the film was written by Orlova. This role makes her popular in Asian countries.

In 2014 Orlova gets the main role in Hollywood film "White crows". She stars with Eric Roberts in the film about Frank Sinatra "Frank and Ava". After this role Marina becomes a member of Hollywood actors guild SAG-Aftra. However, Marina does not forget Europe and Asia. She stars in films, plays at the theater, works as a model with Russian and Italian designers, as well as participates in concerts with her songs. Most striking was her performance on the stage of the Grand Kremlin Palace with the Caruso song accompanied by an orchestra of Naples and Italian singer Renzo Arbore. As well as a tour in Russia with her songs.