Mark was born to parents Osvaldo and Carmelina Venturini (née DeAngelis) and raised in Illinois. He had two brothers, Ralph (born 1959), Patrick (born 1964) and a sister Emily (born 1967). He attended West Leyden High School where he played football and wrestling. After graduation, he quickly pursued his acting career. He moved to California at sometime in his early 20s and began his acting career. His father owned a sandwich store in Illinois called Ozzie's. His children, including Mark, often worked there to help out.

He was perhaps best known for his role in movies like Friday the 13th: A New Beginning (1985) as Victor, and The Return of the Living Dead as Suicide (1985). Mark's final movie was in the movie Out-of-Sync (1995). He made guest appearances on television series like Fantasy Island, Knight Rider, Charles in Charge, Murder, She Wrote, Falcon Crest and Space Rangers.

Mark died from leukemia on Valentine's Day 1996 at age 35. He was buried in Queen of Heaven Cemetery in Hillside, Illinois.