The Group Leader (played by Jere Burns) is a counselor who leads group therapy sessions at Narcotics Anonymous. His real name is not revealed. He takes a calm, non-judgmental approach to leading discussions and emphasizes that those attending his sessions are there not to improve themselves, but to learn self-acceptance. During an outdoor session at a campfire, he reveals to Jesse and other recovering addicts that in July 1992, while drunk on vodka and high on cocaine, he killed his six-year-old daughter by accidentally hitting her with his car. Jesse, still reeling from Jane's death, asks the Group Leader how can he not hate himself for what happened. The Group Leader responds that self-hatred and guilt stand in the way of achieving true change. The Group Leader is seen again in Season 4, when Jesse returns to a session distraught about killing Gale. During the session, Jesse nearly breaks down and yells at the Group Leader, claiming that his philosophy about "accepting yourself" for making mistakes is wrong and people should be judged for the things they have done. Jesse then asks the Group Leader if he just accepts himself for killing his daughter and admits to the whole group that the only reason he comes to these meetings in the first place is to sell meth to them. He asks the Group Leader if he's okay with that, to which the group leader responds, "No." Jesse retorts, "About time," and leaves the session, never to return.

In a flashback to 1999, he delivers a tribute, on behalf of Gus, to Don Eladio in his hacienda. Hector, who is also present with Ximenez Lercerda, the Salamanca's driver and smuggler, is embarrassed by how much money Gus is bringing in. In "Lantern," Gus and Bolsa meet with Hector; the latter of the two reiterates that Hector's products must be distributed through Gus' Los Pollos Hermanos trucks. When Hector suffers a heart attack, Bolsa is forced to flee since he must not be seen with him.

Gomez was originally set to die in the first season. However, when the 2007–2008 writers' strike cut the season short, the Writers reworked their ideas and he remained alive.

Jane Margolis (played by Krysten Ritter) is Jesse's neighbor, landlady, and lover. She is a prolific drafter, a skill that she has used to become a tattoo Artist despite not having any tattoos. She is also a recovering drug addict. She discovers that Jesse also has a history of drawing, and each is intrigued by the other. Jane carries an aloof air but she and Jesse quickly become a couple. She relapses into drug addiction and introduces Jesse to heroin. She later phones Walt and threatens to expose him if he refuses to give Jesse his share of money from a major methamphetamine deal with Gus Fring, a deal that Jesse had nearly ruined by his drug use. Her actions work. After Walt drops off Jesse's cut of nearly a half million dollars to his duplex apartment, she and Jesse discuss running away together to New Zealand to start new lives. They then enter Jesse's bedroom and see the heroin, but instead of throwing it away as they had promised themselves earlier, they get high and fall asleep. That night Walt returns to the apartment and finds the drugged-out couple unconscious in bed. In the process of trying to wake Jesse from his stupor, Walt accidentally turns Jane on her back. Still asleep, she soon begins to vomit, and Walt silently stands at the bedside watching her choke and then die from asphyxiation. Although Walt did not deliberately create the circumstances of Jane's demise, he did choose to do nothing to prevent her death once he saw her choking. Series creator Vince Gilligan later explained Walt's motive for allowing Jane to die. In 2013, during a panel discussion about Breaking Bad in New York City for the Film Society of Lincoln Center, he stated that Walt was afraid that Jane's bad influence would lead Jesse to an early death from a heroin overdose.

In season 4, Ted meets with Skyler, who is now running a car wash, and notifies her of the IRS' Criminal investigation into his company's tax fraud. Since Skyler is heavily linked to Ted's tax fraud, and her entire family would be put under surveillance if the investigation were to proceed, she intervenes by pretending to be a ditzy accountant at Ted's meeting with the IRS. While her show of incompetence (allegedly using Quicken to handle the company's accounting and ignoring electronic transactions) forestalls a full investigation, provided he pays his back taxes and penalties, she must still deal with his poor financial standing and ensure he complies with the IRS' stipulation. Skyler arranges for Ted to receive money to pay off his IRS obligations by having Saul manufacture a dead relative in Luxembourg who leaves Ted a sizable inheritance. However, a follow up by Saul reveals that Ted has leased a new Mercedes and is using the funds to reopen his Business. When Skyler urges Ted to pay the IRS first, he refuses and tells her to leave. Seeing no alternative, Skyler is forced to reveal it is she who gave Ted the money. Ted still refuses to pay the IRS, as he will lose his home and social status, regardless. Skyler perceives his motive to be blackmail; she thinks he expects her to foot not only his tax bill but his other obligations as well. With no other options, Skyler has Saul Goodman send two of his men—Huell and Kuby—to force Beneke to write the check. They succeed, but Beneke then panics and attempts to flee. In the process, he trips on a loose rug and crashes headfirst into a counter.

Dan Wachsberger (played by Chris Freihofer) is an attorney hired by Mike Ehrmantraut to represent Ron Forenall, Dennis Markowski, and the other seven surviving members of Gustavo Fring's operation running out of the Lavanderia Brilliante in Albuquerque. Wachsberger takes the money (Mike Ehrmantraut's "Legacy Costs") from Mike and then deposits it to ten safety deposit boxes at the Cradock Marine Bank in Albuquerque: nine for Fring's surviving guys and their families to use in lieu of their "hazard pay" and one larger box for Mike's granddaughter Kaylee on her 18th birthday.

Dr. Barry Goodman (played by JB Blanc) is Gus's personal Doctor, treating him and Mike after the showdown at Don Eladio's residence. He later informs Mike about Gus's death. He reappears in Better Call Saul as the Doctor on a medical clinic for low income Spanish speaking patients. Per Gus’ instructions, he provides Mike with cocaine to prepare a trap for Hector’s smugglers when they cross the border.