At the age of 17, Page moved to Hollywood to further employment in acting. He gained minor roles on soap operas, including General Hospital. He took coursework at the Art Center College of Design, and in 1989 for a class on product-design he created a machine apparatus similar to that used by the character portrayed by Sigourney Weaver in the film Aliens. He received his degree in industrial design from that institution with honors in 1990. Following his graduation, Page instructed students at the Switzerland location of the Art Center College of Design. Along with his studio partner Scott Robertson, he began work in the field of design consulting.

From July through August 2010, the Oceanside Museum of Art held an exhibition on Page. Titled: "From Page to Screen: Character and Creature Design of Neville Page", featuring works by Page, including pencil drawings, three-dimensional Models, and digital creations. Page said he hoped the exhibit would educate the public about a different facet to filmmaking, "The general public tends to associate films with actors versus people who conceive and design and make the films. What is on display is one small facet of what it takes to make a movie, one of the many gears involved in the mechanism, neither more important nor less ... simply as important."

In the 2011 book Star Wars vs. Star Trek: Could the Empire kick the Federation's ass? And other galaxy-shaking enigmas, author Matt Forbeck characterized Neville Page as a "creature guru". Cloverfield Director Matt Reeves spoke highly of his work with Page, "... he is a genius." Reeves characterized Page's work on the "creature" in the film, "It developed in many different ways, and it came down to what Neville was doing, which was amazing."

Neville has served as a judge on the SyFy television series Face Off. He joined the judging panel on Face Off in season three, which launched in August 2012. His fellow judges included Ve Neill and Glenn Hetrick. Page returned for the fourth season in 2013. In October 2012, Page returned to the Oceanside Museum of Art, with an exhibition titled, "The Beauty in the Beast: Crafting Creatures by Neville Page". The exhibit which ran for ten weeks featured 45 works by Page from films, including Green Lantern, Prometheus, and TRON: Legacy. He was the creature designer for the 2013 American science fiction action film Star Trek Into Darkness.