Lincoln's first picture was The Realization of a Negro's Ambition (1916). For four years Johnson managed to keep Lincoln a going concern, primarily through his extraordinary commitment to African-American filmmaking. However, he reluctantly resigned as President in 1920, as he no longer could continue his double Business life, maintaining a demanding career in Hollywood films while trying to run a studio.

In the 1920s Johnson was a very busy character actor, appearing in such top-notch silent films as The Four Horsemen of the Apocalypse (1921) with Rudolph Valentino, Cecil B. DeMille's original The Ten Commandments (1923), The Thief of Bagdad (1924), and Dante's Inferno (1924). He made the transition to talkies, appearing in The Mysterious Dr. Fu Manchu (1929) as Li Po, in Moby Dick (1930) as Queequeg to John Barrymore's Captain Ahab, and in the Boris Karloff film The Mummy (1932) as "the Nubian". He was also the Native Chief on Skull Island in the classic King Kong (1933) (and its sequel The Son of Kong, 1933) and appeared in Frank Capra's classic Lost Horizon (1937) as one of the porters. One of his last films was John Ford's classic She Wore a Yellow Ribbon (1949), in which he played Native American Chief Red Shirt. He retired from the movie industry in 1950.

Standing 6'2" at 215 pounds, his impressive physique and handsome features made him in demand as a character actor and bit player. In the silent era he assayed a wide variety of characters of different races in a plethora of films, primarily serials, westerns and adventure movies. While Johnson was cast as black in many films, he also played Native American and Latino parts and "exotic" characters such as Arabians or even a devil in hell in Dante's Inferno (1924).

The old orthochromatic film stock of the early days was less discriminating about a person's color, as were black and white stocks in general, permitting some African-American actors a break, as their "color" was washed out or less obvious when photographed in black and white. As late as the early 1960s, there were very few African-American members of the Screen Actors Guild. Since there was a lack of opportunity for them as black performers, they were confined mostly to race films until the 1960s.

Johnson died of natural causes on January 9, 1978, in Yucaipa, California. He is buried in the Garden of Peace at Eternal Valley Memorial Park in Newhall, California.