In 2010, Niall Horan, Zayn Malik, Liam Payne, Harry Styles, and Louis Tomlinson auditioned as solo candidates for the seventh series of the British televised singing competition The X Factor. They failed to progress to the "Boys" category at "judges' houses" but were put together to form a five-piece boy band at Wembley Arena, in London, England, in July 2010, during the "bootcamp" stage of the competition, thus qualifying for the "Groups" category. Nicole Scherzinger, a guest judge, and Simon Cowell have both claimed to have come up with the idea of forming the band. In 2013, Cowell said that it "took him 10 minutes to put them together as a group". Subsequently, the group got together for two weeks to get to know each other and to practice. Styles came up with the name One Direction. For their qualifying song at "judges' houses", and their first song as a group, One Direction sang an acoustic version of "Torn". Cowell later commented that their performance convinced him that they "were confident, fun, like a gang of friends, and kind of fearless as well." Within the first four weeks of the live shows, they were his last act in the competition. The group quickly gained popularity in the UK.

In 2011, the band performed on the BBC's Children in Need 2011 charity telethon, helping raise over 26 million pounds. In 2012 they extended their involvement with Children in Need as they opened the telecast with a performance of their single "Live While We're Young". A prominent annual event in British culture, the group said it was "incredible" to be involved in Children in Need as it was something that they had "always watched as children".

In September 2012, Niall Horan organised an event to raise money for Irish Autism Action and another charity, called Temporary Emergency Accommodation Mullingar, based in his hometown. Due to overwhelming demand to participate in the fundraising, the ticket website for the event broke down. Horan's brother Greg commented on the website crash, saying that "there were 500 tickets and they were all snapped up pretty quick".

Sonny Takhar, the chief executive officer of Syco Records, attributes the breakthrough to the power of social media. "Sometimes you feel the song's the star, but it's not like that here – it's the act," he said. "It's a real moment. Social media has become the new radio, it's never broken an act globally like this before." Will Bloomfield, the group's manager, added, "These guys live online, and so do their fans." Their management employs a social media team and the members all tweet themselves, "which helps create the illusion that they couldn't be any closer to their fans," according to Caspar Llewellyn Smith, writing for The Guardian. One Direction's Twitter account had amassed 10 million followers by February 2013, with the account gaining followers at an average of 21,000 per day. In an approach pioneered by The Beatles, each member is known for his feature; Horan is "the cute one", Malik is "the quiet and mysterious one", Payne is "the sensible one", Styles is "the charming one" and Tomlinson is "the funny one". Each member's individual identity is reinforced by their intentionally different personal styles. Caroline Watson, the band's original Stylist, spoke about styling the band, "At the beginning I didn't want them all in black or all in leather—that whole stereotypical boy band thing." Instead, her original idea was for them to be the "male equivalent to the Spice Girls", with each member being a part of the group but still having his own individual style. Horan commented on One Direction as a boy band, "People think that a boy band is air-grabs and [being] dressed in all one colour. We're boys in a band. We're trying to do something different from what people would think is the typical kind of boy band. We're trying to do different kinds of music and we're just trying to be ourselves, not squeaky clean." Leah Collins, writing for the National Post, remarked that One Direction had succeeded on the latter front, "For the most part, that just means the group presents themselves as typical, goofy and uncensored teenage boys – posting jokey YouTube videos, for instance, or boozing at awards shows." Writing for The Observer, Kitty Empire opined, "One Direction fulfill a great many boy band prerequisites (looks, soppy lyrics, tune-grasp, fame-lust) but their lack of routines points to the subtle digressions afoot here".

One Direction has received five BRIT Awards—winning their first with "What Makes You Beautiful" for Best British Single at the 2012 BRIT Awards, three NME awards, two Kids' Choice Awards, and four MTV Video Music Awards, among other awards. One Direction won 27 awards from 29 they have been nominated for at the Teen Choice Awards. One Direction also won two American Music Awards out of their two nominations for Favorite Pop/Rock Album and Favorite Pop/Rock Band/Duo/Group, respectively.

On 31 July 2015, the group released "Drag Me Down" without promotional material or announcement. The single is the first single from their fifth studio album, Made in the A.M., and the first material released by the group after Malik's departure. Following the release, it was revealed that the group would going on hiatus in 2016 to take a break. On 22 September, the title for the fifth studio album, Made in the A.M., was officially announced along with promotional single "Infinity" being released. The group began to reveal the track listing on their Snapchat stories to which it was later confirmed on iTunes. The album was released on 13 November 2015. At the 2015 American Music Awards on 22 November, One Direction won the award for Artist of the Year for the second year in succession. Louis Tomlinson later confirmed that the break would be around 18 months. On 13 December, One Direction performed on The X Factor final. Their last televised performance as a group, before their hiatus, was on Dick Clark's New Year's Rockin' Eve on 31 December 2015.

On 13 January 2016, Us Weekly published a report claiming that the group's hiatus would become a permanent split, with a "source" citing that each of the four remaining group members did not renew their contracts following the completion of the on the Road Again Tour in October 2015. Representatives for the group denied said-report in a statement to Billboard, stating, "nothing has changed regarding hiatus plans for the group, and all will be revealed in due time from the band members' own mouths." By May 2017, all members of the group had released solo singles. Despite saying the hiatus would last 18 months, the band still are yet to confirm when they will reform.

At the 2017 Brit Awards, One Direction won the Video of the Year award for their song "History". Payne accepted the award on the behalf of the band.

In February 2018, it was reported that the group has folded its touring company, making any chances of a reunion obsolete. The company previously applied for removal within the Companies House registry in October 2017. In just over five years together they have impressively sold more than 70 million records, have achieved over 100 number ones and performed to over 10 million fans worldwide.