At age 18, Ketcham answered an ad in a San Diego paper, through which she entered the pornographic film Business. She performed scenes in well over 200 pornographic features, originally filmed between 2002 and 2009 (although some have been released after she retired).

In 2005, Ketcham directed an instructional video for Shane's World Studios. She also directed the pornographic films Shane's World: Girls Night Out 1-3, Blazed and Confused 1-3 and Penny Flame's Out of Control. In 2008, she signed a deal with Vivid Entertainment and Tristan Taormino to direct her own line of movies under the studio's sex education imprint, Vivid-Ed; the first film was "Penny Flame's Expert Guide to Handjobs", and the second "Penny Flame's Expert Guide to Rough Sex". She retired from the industry in 2009 to enroll in college, and to work as a Writer and Illustrator.

In December 2009, Ketcham began contributing to the Huffington Post, on the inauguration of their Los Angeles edition.

Ketcham discussed her path into pornography and her recovery from addiction with Pinsky and others in a March 17, 2010, appearance on The View. She explained that she had taken a year-long vow of abstinence when she completed treatment. Nine months into this period of abstinence, a friendship with a man who supported her recovery and attended "12-step" meetings with her became a committed, monogamous relationship.

She published a memoir in July 2012 titled I Am Jennie.