In 1973 he entered the Conservatory to study music theory, percussion and music history. Influenced by the punk movement, he created in 1974 the band Hubble Bubble, sharing his time between study at the Conservatory, rehearsals and concerts with the band, and work as stage manager at the Theatre des Galeries. In 1978 Hubble Bubble released their first of two albums, also titled Hubble Bubble. Jouret is credited as the Songwriter, singer and Drummer under the name "Roger Junior". Unfortunately, the group's bass player was killed in an accident returning from a rehearsal, and the group disbanded.

In 1977, Plastic Bertrand started his solo career as the credited Artist of the international hit single "Ça plane pour moi", though in fact the song had been sung and produced by its Composer Lou Deprijck with the Engineer Phil Delire for RKM/Vogue at Studio Morgan in Brussels. Plastic Bertrand received only 0.5% of the song's royalties. A few months earlier, Lou Deprijck had cooperated with Elton Motello (aka Alan Ward), who wrote English lyrics for the same track and recorded it as "Jet Boy, Jet Girl."

Twenty years after "Ça plane pour moi", Bertrand returned to the public eye as MTV declared him the "most wanted comeback artist". He made a guest appearance on the album Get Ready!, and rerecorded the 1982 song "Stop ou encore", which went originally platinum in Belgium. A "best of" album was released in 1998 on the Universal-AMC label, Bertrand himself handling the remastering process.

"Ça plane pour moi" is featured in the 1985 picture National Lampoon's European Vacation, in Danny Boyle's 2010 film 127 Hours, in the 2012 film Ruby Sparks and in the 2013 film The Wolf of Wall Street. The song is also used as the Soundtrack for a commercial spot for Time Warner Cable in the US (April 2011).

In 1987 he represented Luxembourg in the Eurovision Song Contest with the song "Amour Amour". This failed to impress the juries, however, scoring only 4 points and placing 21st out of 22 entries.

During the 1990s Bertrand explored other facets of music, including songwriting and producing, and also recorded the album Suite Diagonal for Sony in 1994 with Jacques Lanzmann. Forming the company MMD with Pierrette Broodthaers, he produced two albums for David Janssen, an album of classical music with a Turkish contemporary influence for harpsichord and organ with Leila Pinar, an album of traditional Balkan music with the Kazansky choir, and a single for Noël Godin, "Chantilly c'est parti". Bertrand's track "Stop ou Encore" (the voice on the tape is actually Lou Deprijck's voice) featured prominently in the 1999 film Three Kings.

In 2001, Bertrand toured Belgium, France, Switzerland and Germany with a series of concerts, and composed a number of new songs. He also made appearances on Channel 4's Eurotrash show and BBC2's chat show Clarkson.

In 2002, he signed a new contract and recorded his eighth album Ultra terrestre, released in Belgium in 2002. In September and November the same year, he managed the TV talent contest Star Academy on RTL-TVI.

In March 2003, to celebrate 25 years since the beginning of his successful solo career, Bertrand performed a concert at the Cirque Royal in Brussels, performing new songs and past hits with a philharmonic orchestra, and singing in duet with guest Singers.

From July to September 2003, he presented the TV show Hit Story on France 3. During his comeback, he appeared on a special 1980s edition of Le Maillon Faible, the French equivalent of The Weakest Link. He won €1,150 for charity. He appeared at the Countdown Spectacular 2 Tour from 18 August to 5 September 2007 in all major capital cities of Australia. In 2011, "Ca Plane Pour Moi" was used as the opening title theme for Jackass 3.5 (2011).

In 2010, an expert appointed by a court stated that the voice of Lou Deprijck, the composer/producer of "Ça plane pour moi", on a record from 2006 is the same voice as on the original 1977 recording. "Today it appears from the report of the experts that the voice of 'Ça plane pour moi' is Lou Deprijck's voice," stated the newspaper La Dernière Heure on Monday, 26 July 2010. Plastic Bertrand previously disputed the allegation, but on 28 July 2010 the singer finally revealed that he is indeed not the singer of any of the songs in the first four albums released under the name Plastic Bertrand.