Prince George's birth marked the second time that three generations of direct heirs to the British throne have been alive at the same time, a situation that last occurred between 1894 and 1901, in the last seven years of the reign of Queen Victoria.

Prince George's official title and style is His Royal Highness Prince George of Cambridge. While his name was announced two days after his birth, he was, from birth, a British Prince entitled to the style of Royal Highness under letters patent issued by his great-great-great grandfather, King George V in 1917, which gave the title and style to the eldest son of the Prince of Wales's eldest son. Letters patent issued on 31 December 2012 by Queen Elizabeth II extended the 1917 patent so that all children of the Prince of Wales's eldest son are princes or princesses with the style Royal Highness. As with other princes and princesses who are born to royal dukes, George's territorial designation is taken from his father's title, in this case "Cambridge", from Duke of Cambridge.

Prince George was baptised by the Archbishop of Canterbury in the Chapel Royal at St James's Palace on 23 October 2013, with Oliver Baker, Emilia Jardine-Paterson, Hugh Grosvenor, 7th Duke of Westminster, Jamie Lowther-Pinkerton, The Hon. Julia Samuel, william van Cutsem and Zara Tindall serving as godparents. The ceremony used a font that was made for Queen Victoria's first child and water from the River Jordan. The Royal Mint issued a set of commemorative coins to celebrate the christening, the first coins to mark a royal christening in Britain.

The Prince George effect, also known as the royal baby effect, is the trend that news about Prince George has in Business and pop culture, similar to his mother's. Clothing and products identified as used by George tend to sell better than before. The effect was noted during his April 2014 tour of New Zealand and Australia and many businesses have attempted to use this effect to their advantage. He was ranked No. 49 on GQ's "50 Best Dressed Men in Britain" list in 2015. In 2016, the dressing gown he wore while meeting President Obama sold out after he was seen wearing it. In September 2017 the news that the prince's school had served a Le Puy green lentil dish resulted in a spike in the legume's sales.

On 2 May 2015, George visited the hospital of his birth after the birth of his sister, Charlotte. It was his first public appearance in the United Kingdom since shortly after his birth. He made his first public appearance on the balcony of Buckingham Palace following the Trooping the Colour parade on 13 June that year, to watch a flypast by the Red Arrows on the Queen's Official Birthday. In August 2015, Kensington Palace stated that they wanted all global media to stop taking unauthorised photographs of George, as they believed "a line has been crossed" in paparazzi methods of locating and photographing him.

In January 2016, George started his education at the Westacre Montessori School Nursery, near his family home at Anmer Hall in Norfolk. That April, he was photographed for postage stamps to mark his great-grandmother's 90th birthday, alongside his father and grandfather. On 22 April of that year, he met President of the United States Barack Obama. He was photographed with a rocking horse that Obama had given him when he was born. The encounter later prompted Obama to joke that "Prince George showed up to our meeting in his bathrobe... a clear breach of protocol."

Prince George attended his first day of primary school on 7 September 2017 at the private Thomas's School in Battersea. Prince George uses the name "George Cambridge" at school.