After the Reformation, Muhammad was often portrayed in a similar way. Guillaume Postel was among the first to present a more positive view of Muhammad when he argued that Muhammad should be esteemed by Christians as a valid prophet. Gottfried Leibniz praised Muhammad because "he did not deviate from the natural religion". Henri de Boulainvilliers, in his Vie de Mahomed which was published posthumously in 1730, described Muhammad as a gifted political leader and a just lawmaker. He presents him as a divinely inspired messenger whom God employed to confound the bickering Oriental Christians, to liberate the Orient from the despotic rule of the Romans and Persians, and to spread the knowledge of the unity of God from India to Spain. Voltaire had a somewhat mixed opinion on Muhammad: in his play Le fanatisme, ou Mahomet le Prophète he vilifies Muhammad as a symbol of fanaticism, and in a published essay in 1748 he calls him "a sublime and hearty charlatan", but in his historical survey Essai sur les mœurs, he presents him as legislator and a conqueror and calls him an "enthusiast." Jean-Jacques Rousseau, in his Social Contract (1762), "brushing aside hostile legends of Muhammad as a trickster and impostor, presents him as a sage legislator who wisely fused religious and political powers." Emmanuel Pastoret published in 1787 his Zoroaster, Confucius and Muhammad, in which he presents the lives of these three "great men", "the greatest legislators of the universe", and compares their careers as religious reformers and lawgivers. He rejects the Common view that Muhammad is an impostor and argues that the Quran proffers "the most sublime truths of cult and morals"; it defines the unity of God with an "admirable concision." Pastoret writes that the Common accusations of his immorality are unfounded: on the contrary, his law enjoins sobriety, generosity, and compassion on his followers: the "legislator of Arabia" was "a great man." Napoleon Bonaparte admired Muhammad and Islam, and described him as a model lawmaker and a great man. Thomas Carlyle in his book Heroes and Hero Worship and the Heroic in History (1840) describes Muhammad as "[a] silent great soul; [...] one of those who cannot but be in earnest". Carlyle's interpretation has been widely cited by Muslim scholars as a demonstration that Western scholarship validates Muhammad's status as a great man in history.

Academics Reşit Haylamaz and Fatih Harpci say that Ar-Rafiq Al-A'la is referring to God. He was buried where he died in Aisha's house. During the reign of the Umayyad caliph al-Walid I, al-Masjid an-Nabawi (the Mosque of the Prophet) was expanded to include the site of Muhammad's tomb. The Green Dome above the tomb was built by the Mamluk Sultan Al Mansur Qalawun in the 13th century, although the green color was added in the 16th century, under the reign of Ottoman Sultan Suleiman the Magnificent. Among tombs adjacent to that of Muhammad are those of his companions (Sahabah), the first two Muslim caliphs Abu Bakr and Umar, and an empty one that Muslims believe awaits Jesus. When bin Saud took Medina in 1805, Muhammad's tomb was stripped of its gold and jewel ornaments. Adherents to Wahhabism, bin Saud's followers destroyed nearly every tomb dome in Medina in order to prevent their veneration, and the one of Muhammad is said to have narrowly escaped. Similar events took place in 1925 when the Saudi militias retook—and this time managed to keep—the city. In the Wahhabi interpretation of Islam, burial is to take place in unmarked graves. Although frowned upon by the Saudis, many pilgrims continue to practice a ziyarat—a ritual visit—to the tomb.

In 632, at the end of the tenth year after migration to Medina, Muhammad completed his first true Islamic pilgrimage, setting precedence for the annual Great Pilgrimage, known as Hajj. On the 9th of Dhu al-Hijjah Muhammad delivered his Farewell Sermon, at Mount Arafat east of Mecca. In this sermon, Muhammad advised his followers not to follow certain pre-Islamic customs. For instance, he said a white has no superiority over a black, nor a black has any superiority over a white except by piety and good action. He abolished old blood feuds and disputes based on the former tribal system and asked for old pledges to be returned as implications of the creation of the new Islamic community. Commenting on the vulnerability of women in his society, Muhammad asked his male followers to "be good to women, for they are powerless captives (awan) in your households. You took them in God's trust, and legitimated your sexual relations with the Word of God, so come to your senses people, and hear my words ..." He told them that they were entitled to discipline their wives but should do so with kindness. He addressed the issue of inheritance by forbidding false claims of paternity or of a client relationship to the deceased and forbade his followers to leave their wealth to a testamentary heir. He also upheld the sacredness of four lunar months in each year. According to Sunni tafsir, the following Quranic verse was delivered during this event: "Today I have perfected your religion, and completed my favours for you and chosen Islam as a religion for you" (Quran 5:3). According to Shia tafsir, it refers to the appointment of Ali ibn Abi Talib at the pond of Khumm as Muhammad's successor, this occurring a few days later when Muslims were returning from Mecca to Medina.

According to Hossein Nasr, the earliest European literature often refers to Muhammad unfavorably. A few learned circles of Middle Ages Europe – primarily Latin-literate scholars – had access to fairly extensive biographical material about Muhammad. They interpreted the biography through a Christian religious filter; one that viewed Muhammad as a person who seduced the Saracens into his submission under religious guise. Popular European literature of the time portrayed Muhammad as though he were worshipped by Muslims, similar to an idol or a heathen god.

However, there is a completely different story on the reason why the Muslims returned from Ethiopia to Mecca. According to this account—initially mentioned by Al-Waqidi then rehashed by Ibn Sa'ad and Tabari, but not by Ibn Hisham and not by Ibn Ishaq—Muhammad, desperately hoping for an accommodation with his tribe, pronounced a verse acknowledging the existence of three Meccan goddesses considered to be the daughters of Allah. Muhammad retracted the verses the next day at the behest of Gabriel, claiming that the verses were whispered by the devil himself. Instead, a ridicule of these gods was offered. This episode, known as "The Story of the Cranes," is also known as "Satanic Verses". According to the story, this led to a general reconciliation between Muḥammad and the Meccans, and the Abyssinia Muslims began to return home. When they arrived Gabriel had informed Muḥammad the two verses were not part of the revelation, but had been inserted by Satan. Notable scholars at the time argued against the historic authenticity of these verses and the story itself on various grounds. Al-Waqidi was severely criticized by Islamic scholars such as Malik ibn Anas, al-Shafi'i, Ahmad ibn Hanbal, Al-Nasa'i, al-Bukhari, Abu Dawood, Al-Nawawi and others as a liar and forger. Later, the incident received some acceptance among certain groups, though strong objections to it continued onwards past the tenth century. The objections continued until rejection of these verses and the story itself eventually became the only acceptable orthodox Muslim position.

Abū al-Qāsim Muḥammad ibn ʿAbd Allāh ibn ʿAbd al-Muṭṭalib ibn Hāshim, was born about the year 570 and his birthday is believed to be in the month of Rabi' al-awwal. He belonged to the Banu Hashim clan, part of the Quraysh tribe, and was one of Mecca's prominent families, although it appears less prosperous during Muhammad's early lifetime. Tradition places the year of Muhammad's birth as corresponding with the Year of the Elephant, which is named after the failed destruction of Mecca that year by the Abraha, Yemen's king, who supplemented his army with elephants. Alternatively some 20th century scholars have suggested different years, such as 568 or 569.

Descriptions like these were often reproduced in calligraphic panels (hilya or, in Turkish, hilye), which in the 17th century developed into an art form of their own in the Ottoman Empire.