Quavious Keyate Marshall was born on April 2, 1991, in Athens, Georgia. Marshall's mother was a hairdresser and his father died when he was four years old. The three members of the Migos grew up together in Gwinnett County, a mostly white suburban area half an hour northeast of Atlanta. "I ain't going to sit here like, 'My neighborhood was hard, and I had to get out there and grind.' We made it hard for ourselves. We chose to stay on the streets," Marshall said.

Quavo previously held the record by completing 29 passes in a game back in 2009.

Migos was formed in 2009 by Quavo and fellow Rappers Takeoff and Offset. The three members are directly related and were raised together by Quavo's mother. Quavo is Takeoff's uncle, and Offset is Quavo's cousin. The group was originally known as Polo Club and are from Lawrenceville, Georgia. The group eventually decided to change their name to "Migos" after deciding Polo Club was too generic. The group released their first full-length project, a mixtape titled Juug Season, on August 25, 2011. They followed with the mixtape No Label, on June 1, 2012.

Migos rose to prominence after the release single "Versace", released in 2013. The song was remixed featuring Drake and peaked at number 99 on the Billboard Hot 100 chart and on the Hot R&B/Hip-Hop Songs chart at 31.

On April 18, 2015, authorities stopped a Migos concert at Georgia Southern University and arrested all three members of the group, as well as several members of their entourage. Quavo was charged with possession of an unspecified Schedule II narcotic, possession of marijuana, possession of a firearm in a school safety zone, and possession of a firearm during the commission of a crime. He was released from jail on bond, and later pleaded no contest to misdemeanor marijuana charges and received a 12-month sentence, which was suspended based on payment of fines.

On December 21, 2017, Quavo announced that he would release Huncho Jack, Jack Huncho with Travis Scott on December 22, 2017 without any prior promotion.