In 1985, Goldin starred in the ABC sitcom, Hail to the Chief, playing the son of the first female President of the United States (played by Patty Duke). The series was canceled after one season. Goldin also had a recurring role on the 1980s sitcom Kate & Allie as Allie's daughter Jenny's boyfriend, Jason. He also appeared in the Alf episode titled Stop in the Name of Love (1988). In 1993, he hosted the short-lived, primetime reality dating show Street Match on ABC.

Goldin began dating Actress Yasmine Bleeth in 1989. They became engaged in January 1995. Goldin and Bleeth ended their relationship later that year. Goldin was later engaged to Actress and Playboy model Priscilla Taylor. In November 2001, Goldin married British television presenter Emma Ford. They divorced in 2002.

Goldin is best known for portraying Dean Frame on the NBC daytime drama Another World, a role he played from 1990 to 1993, from 1994 to 1995, and again briefly in 1998. He also appeared on the CBS top daytime drama The Young and the Restless as stalker Gary Dawson from 1999 to 2000.

At aged 15, Goldin appeared in the Broadway production of On Golden Pond. In 1994, he returned to Broadway as Danny Zuko in the Broadway revival of the musical Grease. He followed up with the starring role in the Gilbert & Sullivan operetta Pirates of Penzance in London and Dublin, Ireland. Goldin has also appeared in several off Broadway productions including Nest Of The Wood Grouse, Feathered Serpent, Happy Journey, Queens of France, Long Christmas Dinner, and Our Town.

Goldin has appeared in several made-for-TV movies, including A Face to Die For in 1996 with Yasmine Bleeth. That same year, he also co-starred in Talk to Me, again with Yasmine Bleeth. Among his movie credits, Goldin has had roles in Piranha II: The Spawning (1981), The Blob (1988) and Lambada (1990).

In 2001, he co-created and produced a variety show-style pilot for Viacom called FLY TV. In 2003, Godlin spent time on location in Dubai producing ESPN2's The Celebrity Arabian Adventure, and the in-flight programming for Emirates Airlines. Goldin also created and produced Seeing VS Believing, a one-hour special premiered on TLC in May 2010.

On March 5, 2008, a week after he announced he would be leaving the role of Gus on Guiding Light, Goldin joined All My Children in the recast role of Dr. Joseph "Jake" Martin. In 2010, he was nominated for his third Daytime Emmy Award, his first for his work on All My Children, in the Outstanding Supporting Actor category. In 2011, he was nominated again, this time in the Outstanding Lead Actor category for All My Children. Goldin remained with All My Children through to the final episode on September 23, 2011. Goldin also hosted five Live from the Red Carpet Emmy shows for Disney/ABC. After All My Children ended in September 2011, Goldin was seen on the internet in an on-line advertising web series that was a joint venture between Kellogg's and Disney Family. He appeared in a parody of daytime drama entitled The Young and the Breakfast.

Goldin began dating TV fashion personality Gretta Monahan in 2009. Together, they have two sons — one born in October 2010 and a second in June 2017.

On March 18, 2013, it was announced that Goldin will be joining the CBS soap The Bold and the Beautiful as Jesse Graves on May 15, 2013 on a recurring status. In 2014, Goldin played Andrew Miller in the soap opera web series Beacon Hill. As a Producer for the series, he was nominated for a 2015 Daytime Emmy for Outstanding New Approaches Drama Series.