Joffé was married to actor Jane Lapotaire; they have a son, Screenwriter and Director Rowan Joffé (b. 1973). Later, he and actor Cherie Lunghi were in a longterm relationship; they have a daughter, actor Nathalie Lunghi (b. 1986).

Joffé also directed an episode in BBC's Second City Firsts in 1977 and later directed two more plays for Play for Today: The Legion Hall Bombing (1979) and United Kingdom (1981). In 1979, he directed the TV play No, Mama, No by Verity Bargate for the ITV Playhouse series, and in 1980 he made a version of 17th century dramatist John Ford's play 'Tis Pity She's a Whore as a TV film for the BBC.

Roland Joffé's first two feature films (The Killing Fields, 1984, and The Mission, 1986) each garnered him an Academy Award nomination for Best Director. Joffé worked closely with Producer David Puttnam on each film. The Killing Fields detailed the friendship of two men, an American Journalist for The New York Times, and his translator, a prisoner of the Khmer Rouge in Communist Cambodia. It won three Academy Awards (for Best Supporting Actor, Best Cinematography, and Best Film Editing) and was nominated for four more (including Best Picture and Best Director). The Mission was a story of conflict between Jesuit missionaries in South America, who were trying to convert the Guaraní Indians, and the Portuguese and Spanish colonisers, who wanted to enslave the natives. In an interview with Thomas Bird, Joffé says of The Mission, "The Indians are innocent. The film is about what happens in the world . . . what that innocence brings out in us. You would sit in a cinema in New York, or in Tokyo, or Paris, and for that point of time you would be joined with your companions on this planet. You would come out with a real sense of a network.". The film won the Palme d'Or and Technical Grand Jury Prize at the 1986 Cannes Film Festival. It achieved six Academy Awards nominations—including for Best Picture, Best Director, and Ennio Morricone's acclaimed Best Original Score—and won one, for Best Cinematography.

Since his initial acclaim, Joffé's film career has been less successful. In 1993, he produced and partially directed a big budget adaptation of the video game Super Mario Bros.. The film struggled to make back its budget. His 1995 adaptation of The Scarlet Letter was a critical and financial disaster, and his 2007 horror film Captivity drew controversy with its advertising billboards, widely regarded as exploitative and misogynistic. He received Razzie Nominations for Worst Director for The Scarlet Letter and Captivity.

Joffé was educated at two independent schools: the Lycée français Charles de Gaulle in London, and Carmel College in Wallingford, Oxfordshire, which was Europe's only Jewish boarding school, until it closed in 1997. He completed his formal education at the University of Manchester.

Joffé is a board member of the nonprofit organization Operation USA. He was the official patron of the 2011 Cambodia Volleyball World Cup held from 23 to 29 July at the National Olympic Stadium Phnom Penh.

In 2013 Joffé directed the Anglo-Indian historical epic romance time travel adventure film, The Lovers.