Sabina was born in Rome to a German mother and an Italian father. She lived there until age 5, then moved to Germany with her mother, Painter Hannelore Jüterbock, and her brother, Christian, where she grew up in Berg, Upper Bavaria. After living in Italy, Germany and France, Sciubba later lived in New York from 1999-2009, before returning to France. She has commented on her childhood: "I grew up singing to trees, donkeys, sheep and horses, so I suppose there isn't an audience I'm not prepared for." Sciubba is perfectly fluent in six languages: German, Italian, French, English, Spanish and Portuguese.

Sabina is best known as the frontwoman for the band Brazilian Girls. She is known for her unique voice and her signature multilingual storytelling. She has also been called 'enigmatic' and is noted for her sense of fashion, wearing theatrical outfits often made by herself or by her fashion-designer friends threeasfour, Carolina K, and Gemma Kahng. In 2008 Sabina composed and sang the songs "Bring Back the Love" and "Os Novos Yorkinos" for Bebel Gilberto's album Momento. In 2009, Brazilian Girls were nominated for a Grammy Award in the Best Dance Recording category, but lost out to the band Daft Punk. In 2009 Sabina and Brazilian Girls member Didi Gutman wrote and produced singer Baaba Maal's album Television, released on Palm Pictures.

Sabina released a self-produced video for her single 'Toujours' in 2013. She also made a series of short animated films, which she named Minifilms, which are political comments on human behaviour.

In early April 2014, renowned British Artist Oliver Clegg creates a video for and with Sabina for the single 'Viva l'amour'. The video consists of thousands of hand-drawn images of Sabina.

Beginning in 2016, Sciubba appears alongside Zach Galifianakis as Penelope in the television comedy series Baskets on FX.